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在iPrEx开放标签扩展研究中，头发中替诺福韦（TFV）和恩曲他滨（FTC）浓度与干血斑中替诺福韦二磷酸酯和恩曲他滨三磷酸酯之间的强相关性：对暴露前预防依从性监测的意义。

Strong Correlation Between Concentrations of Tenofovir (TFV) Emtricitabine (FTC) in Hair and TFV Diphosphate and FTC Triphosphate in Dried Blood Spots in the iPrEx Open Label Extension: Implications for Pre-exposure Prophylaxis Adherence Monitoring.

作者信息

Gandhi Monica, Glidden David V, Liu Albert, Anderson Peter L, Horng Howard, Defechereux Patricia, Guanira Juan V, Grinsztejn Beatriz, Chariyalertsak Suwat, Bekker Linda-Gail, Grant Robert M

机构信息

Department of Medicine, University of California.

Department of Epidemiology and Biostatistics, University of California.

出版信息

J Infect Dis. 2015 Nov 1;212(9):1402-6. doi: 10.1093/infdis/jiv239. Epub 2015 Apr 20.

DOI:10.1093/infdis/jiv239
PMID:25895984
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4601920/
Abstract

Self-reported adherence to pre-exposure prophylaxis (PrEP) has limitations, raising interest in pharmacologic monitoring. Drug concentrations in hair and dried blood spots (DBS) are used to assess long-term-exposure; hair shipment/storage occurs at room temperature. The iPrEx Open Label Extension collected DBS routinely, with opt-in hair collection; concentrations were measured with liquid chromatography/tandem mass spectrometry. In 806 hair-DBS pairs, tenofovir (TFV) hair levels and TFV diphosphate (DP) in DBS were strongly correlated (Spearman coefficient r = 0.734; P < .001), as were hair TFV/DBS emtricitabine (FTC) triphosphate (TP) (r = 0.781; P < .001); hair FTC/DBS TFV-DP (r = 0.74; P < .001); hair FTC/DBS FTC-TP (r = 0.587; P < .001). Drug detectability was generally concordant by matrix. Hair TFV/FTC concentrations correlate strongly with DBS levels, which are predictive of PrEP outcomes.

摘要

自我报告的暴露前预防（PrEP）依从性存在局限性，这引发了对药物监测的兴趣。头发和干血斑（DBS）中的药物浓度用于评估长期暴露情况；头发的运输/储存是在室温下进行的。iPrEx开放标签扩展研究常规收集DBS，并通过选择加入的方式收集头发；浓度通过液相色谱/串联质谱法进行测定。在806对头发-DBS样本中，替诺福韦（TFV）的头发水平与DBS中的替诺福韦二磷酸酯（DP）密切相关（斯皮尔曼系数r = 0.734；P < 0.001），头发中的TFV/ DBS中的恩曲他滨（FTC）三磷酸酯（TP）也是如此（r = 0.781；P < 0.001）；头发中的FTC / DBS中的TFV-DP（r = 0.74；P < 0.001）；头发中的FTC / DBS中的FTC-TP（r = 0.587；P < 0.001）。药物的可检测性在不同基质中总体上是一致的。头发中的TFV/FTC浓度与DBS水平密切相关，而DBS水平可预测PrEP的效果。

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[7]
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本文引用的文献

[1]
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J Acquir Immune Defic Syndr. 2015-1-1

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