Sciaranghella Gaia, Wang Cuiwei, Hu Haihong, Anastos Kathryn, Merhi Zaher, Nowicki Marek, Stanczyk Frank Z, Greenblatt Ruth M, Cohen Mardge, Golub Elizabeth T, Watts D Heather, Alter Galit, Young Mary A, Tsibris Athe M N
Ragon Institute of MGH, MIT, and Harvard, Boston, Massachusetts.
Georgetown University Medical Center, Washington D.C.
J Infect Dis. 2015 Nov 1;212(9):1397-401. doi: 10.1093/infdis/jiv233. Epub 2015 Apr 20.
Human immunodeficiency virus (HIV) infectivity increases as receptor/coreceptor expression levels increase. We determined peripheral CD4, CCR5, and CXCR4 expression levels in HIV-uninfected women who used depot medroxyprogesterone acetate (DMPA; n = 32), the levonorgestrel-releasing intrauterine device (LNG-IUD; n = 27), oral contraceptive pills (n = 32), or no hormonal contraception (n = 33). The use of LNG-IUD increased the proportion of CD4(+) and CD8(+) T cells that expressed CCR5; increases in the magnitude of T-cell subset CCR5 expression were observed with DMPA and LNG-IUD use (P < .01 for all comparisons). LNG-IUD and, to a lesser extent, DMPA use were associated with increased peripheral T-cell CCR5 expression.
随着受体/共受体表达水平的升高，人类免疫缺陷病毒（HIV）的感染性增强。我们测定了未感染HIV的女性外周血中CD4、CCR5和CXCR4的表达水平，这些女性分别使用了醋酸甲羟孕酮长效避孕针（DMPA；n = 32）、左炔诺孕酮宫内节育器（LNG-IUD；n = 27）、口服避孕药（n = 32）或未采取激素避孕措施（n = 33）。使用LNG-IUD增加了表达CCR5的CD4(+)和CD8(+) T细胞的比例；使用DMPA和LNG-IUD后，T细胞亚群CCR5表达量增加（所有比较的P < .01）。使用LNG-IUD以及在较小程度上使用DMPA与外周血T细胞CCR5表达增加有关。
