Wenping Sun, Ying Liu, Song Leng, Yuzhong Li, Hui Liu
College of Medical Laboratory, Dalian Medical University, Dalian, 116044, China.
Second Affiliated Hospital of Dalian Medical University, Dalian, China.
J Transl Med. 2015 Apr 22;13:127. doi: 10.1186/s12967-015-0487-z.
To develop a quantitative system to enable the objective assessment of health or pre-chronic disease state.
On the basis of measured values and reference ranges, we obtained the organ function index (mean of the cut-off ratios of albumin and creatinine), blood lipid index (mean of the cut-off ratios of triglycerides, cholesterol, high-density lipoproteins and low-density lipoproteins), stress index (mean of the cut-off ratios of neutrophils and glucose), and the health test index (mean of the above three indexes, HTI). Elderly populations, individuals with nonalcoholic fatty liver disease and administrators were included in the groups of observed subjects to verify the organ function index, blood lipid index and stress index.
The scores of the three indexes were all statistically higher in the observed group than in the control group (p < 0.05). The mean HTI score was 0.7 ± 0.07 and was normally distributed in the control population. The rates of hypertension, obesity, fatty liver disease and health (undetectable organic diseases) increased with increasing HTI scores in a random population.
The HTI is easily derived from routinely measured clinical laboratory parameters. It can reflect the health status of an individual and may be a useful tool for the quantitative differentiation of health status.
开发一种定量系统，以实现对健康或慢性疾病前期状态的客观评估。
基于测量值和参考范围，我们获得了器官功能指数（白蛋白与肌酐截断比值的平均值）、血脂指数（甘油三酯、胆固醇、高密度脂蛋白和低密度脂蛋白截断比值的平均值）、应激指数（中性粒细胞与葡萄糖截断比值的平均值）以及健康测试指数（上述三项指数的平均值，HTI）。观察对象组纳入了老年人群、非酒精性脂肪性肝病患者和管理人员，以验证器官功能指数、血脂指数和应激指数。
观察组三项指数的得分均在统计学上高于对照组（p < 0.05）。HTI平均得分为0.7 ± 0.07，在对照人群中呈正态分布。在随机人群中，高血压、肥胖、脂肪肝疾病和健康（未检测到器质性疾病）的发生率随HTI得分升高而增加。
HTI可轻松从常规测量的临床实验室参数得出。它能反映个体的健康状况，可能是用于健康状况定量区分的有用工具。
