Huang Linjian, Jiang Bin, Cai Xieyi, Zhang Weijie, Qian Wentao, Li Yanjie, Guan Xin, Liang Xiang, Zhou Longnv, Zhu Jian, Zhang Zhiyuan
Resident, Department of Oral Surgery, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai, China; and Department of Oral and Maxillofacial Surgery, The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, China.
Attending Physician, Department of Oral Surgery, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai, China.
J Oral Maxillofac Surg. 2015 Jul;73(7):1320.e1-10. doi: 10.1016/j.joms.2015.04.002. Epub 2015 Apr 8.
To assess the incidence, risk factors, treatment, and outcomes of life-threatening complications of multi-space infections (LCMIs) in the head and neck.
This was a retrospective cohort study that enrolled a sample of patients with multi-space infections who were referred from February 2006 through July 2014. The patients were classified into LCMI and non-LCMI groups. The primary predictor in this study was underlying systemic disease. The primary outcome variable was LCMI. Univariate analyses were used for data statistics.
A total of 549 patients were included, and an LCMI was found in 66 patients (12.20%). Descending mediastinitis was the most frequent LCMI (n = 37; 56.06%), followed by airway obstruction (n = 27; 40.91%), pneumonia (n = 12; 18.18%), pericarditis (n = 6; 9.09%), intraorbital infection (n = 2; 3.03%), multiple organ failure (n = 2; 3.03%), intracranial infection (n = 2; 3.03%), and sudden cardiac death (n = 1; 1.52%). Twelve patients with LCMI died during treatment. Elderly patients with an underlying systemic disease more commonly developed an LCMI.
Multi-space infections in the head and neck can cause several life-threatening complications, and the morbidity of LCMI is considerable. Older age and underlying systemic disease can increase the risk of an LCMI.
评估头颈部多间隙感染（LCMIs）危及生命并发症的发生率、危险因素、治疗及预后。
这是一项回顾性队列研究，纳入了2006年2月至2014年7月间转诊的多间隙感染患者样本。患者被分为LCMI组和非LCMI组。本研究的主要预测因素是潜在的全身性疾病。主要结局变量是LCMI。采用单因素分析进行数据统计。
共纳入549例患者，其中66例（12.20%）发生LCMI。下行性纵隔炎是最常见的LCMI（n = 37；56.06%），其次是气道阻塞（n = 27；40.91%）、肺炎（n = 12；18.18%）、心包炎（n = 6；9.09%）、眶内感染（n = 2；3.03%）、多器官功能衰竭（n = 2；3.03%）、颅内感染（n = 2；3.03%）和心源性猝死（n = 1；1.52%）。12例LCMI患者在治疗期间死亡。患有潜在全身性疾病的老年患者更易发生LCMI。
头颈部多间隙感染可导致多种危及生命的并发症，LCMI的发病率相当高。高龄和潜在的全身性疾病会增加发生LCMI的风险。
