Masaoka Ⅲ期胸腺癌的治疗与预后：32例回顾性研究
Treatment and prognosis of Masaoka stage 3 thymic carcinoma: a retrospective study of 32 cases.
作者信息
Sun Yan, Liu Jinshi, Yu Xinmin
机构信息
Key Laboratory Diagnosis and Treatment Technology on Thoracic Oncology, Hangzhou, People's Republic of China ; Department of Medical Oncology, Zhejiang Cancer Hospital, Hangzhou, People's Republic of China.
Key Laboratory Diagnosis and Treatment Technology on Thoracic Oncology, Hangzhou, People's Republic of China ; Department of Oncological Surgery, Zhejiang Cancer Hospital, Hangzhou, People's Republic of China.
出版信息
Onco Targets Ther. 2015 Apr 6;8:699-702. doi: 10.2147/OTT.S78791. eCollection 2015.
PURPOSE
The aim of this study was to investigate the treatment and prognostic factors in patients with Masaoka stage 3 thymic carcinoma.
METHODS
A retrospective review was conducted of the medical records of patients with Masaoka stage 3 thymic carcinoma between 2000 and 2012 in our institution. Clinical characteristics and prognostic factors were analyzed. Survival curves were plotted using the Kaplan-Meier method. The Cox proportional hazard model was used for multivariate analysis.
RESULTS
Thirty-two patients with Masaoka stage 3 thymic carcinoma, operated on in Zhejiang Cancer Hospital, were identified between 2000 and 2012. Among 32 patients, 24 achieved R0 resection. The most common histological subtypes were squamous cell carcinoma (n=15, 46.8%), followed by undifferentiated carcinoma (n=12, 37.5%), and other tumors (n=5, 15.7%). The 5-year disease-free survival and overall survival rates were 56.8% and 61.5%, respectively. Patients with incomplete resection had a significantly worse disease-free survival and overall survival as compared to complete resection with univariate analyses (P-value 0.006 and 0.034, respectively). Multivariate analysis revealed that complete resection was statistically associated with disease-free survival but not overall survival (P-value 0.025 and 0.076, respectively).
CONCLUSION
Our results indicated that complete resection could impact the disease-free survival of patients with stage 3 thymic carcinoma.
目的
本研究旨在调查Masaoka 3期胸腺癌患者的治疗及预后因素。
方法
对2000年至2012年间我院收治的Masaoka 3期胸腺癌患者的病历进行回顾性分析。分析临床特征及预后因素。采用Kaplan-Meier法绘制生存曲线。使用Cox比例风险模型进行多因素分析。
结果
2000年至2012年间，共识别出32例在浙江省肿瘤医院接受手术的Masaoka 3期胸腺癌患者。32例患者中，24例实现R0切除。最常见的组织学亚型为鳞状细胞癌（n = 15，46.8%），其次为未分化癌（n = 12，37.5%），其他肿瘤（n = 5，15.7%）。5年无病生存率和总生存率分别为56.8%和61.5%。单因素分析显示，与完整切除相比，不完全切除患者的无病生存率和总生存率显著更差（P值分别为0.006和0.034）。多因素分析显示，完整切除与无病生存率在统计学上相关，但与总生存率无关（P值分别为0.025和0.076）。
结论
我们的结果表明，完整切除可影响3期胸腺癌患者的无病生存率。
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