Plauzolles Anne, Lucas Michaela, Gaudieri Silvana
Centre for Forensic Science, University of Western Australia, Perth, WA, Australia.
School of Medicine and Pharmacology, Harry Perkins Institute, University of Western Australia, Perth, WA, Australia ; School of Pathology and Laboratory Medicine, University of Western Australia, Perth, WA, Australia.
Infect Drug Resist. 2015 Apr 7;8:63-74. doi: 10.2147/IDR.S49891. eCollection 2015.
Genetic and cellular studies have shown that the host's innate and adaptive immune responses are an important correlate of viral infection outcome. The features of the host's immune response (host resistance) reflect the coevolution between hosts and pathogens that has occurred over millennia, and that has also resulted in a number of strategies developed by viruses to improve fitness and survival within the host (viral adaptation). In this review, we discuss viral adaptation to host immune pressure via protein-protein interactions and sequence-specific mutations. Specifically, we will present the "state of play" on viral escape mutations to host T-cell responses in the context of the hepatitis C virus, and their influence on infection outcome.
遗传学和细胞研究表明，宿主的先天性和适应性免疫反应是病毒感染结果的一个重要相关因素。宿主免疫反应（宿主抵抗力）的特征反映了宿主与病原体之间历经数千年的共同进化，这也导致病毒形成了一些策略来提高其在宿主体内的适应性和生存能力（病毒适应性）。在本综述中，我们将讨论病毒通过蛋白质-蛋白质相互作用和序列特异性突变对宿主免疫压力的适应性。具体而言，我们将介绍丙型肝炎病毒背景下病毒逃避宿主T细胞反应的突变的“进展情况”，以及它们对感染结果的影响。
