Chen Shao-Ru, Chen Xiu-Ping, Lu Jin-Jian, Wang Ying, Wang Yi-Tao
State Key Laboratory of Quality Research in Chinese Medicine, and Institute of Chinese Medical Sciences, University of Macau, Macao, SAR China.
Chin Med. 2015 Apr 15;10:7. doi: 10.1186/s13020-015-0036-y. eCollection 2015.
Liver fibrosis is a wound-healing response to chronic liver injury characterized by progressive inflammation and deposition of extracellular matrix components. The pathological condition of liver fibrosis involves secretion of extracellular matrix proteins and formation of scar tissue. The major regulators involved in hepatic fibrogenesis are the transforming growth factor (TGF)-β1/SMAD and toll-like receptor 4 (TLR4)-initiated myeloid differentiation primary response 88 gene (MyD88)/NF-ĸB cell signaling pathways. This article reviews natural products and herbal medicines that have demonstrated activity against liver fibrosis through different mechanisms of action, including anti-hepatitis B and C virus activity, anti-inflammation, inhibition of cytokine production and nuclear receptor activation, and free radical scavenging.
肝纤维化是对慢性肝损伤的一种伤口愈合反应，其特征为进行性炎症和细胞外基质成分的沉积。肝纤维化的病理状况涉及细胞外基质蛋白的分泌和瘢痕组织的形成。参与肝纤维化形成的主要调节因子是转化生长因子（TGF）-β1/SMAD和Toll样受体4（TLR4）启动的髓样分化初级反应88基因（MyD88）/核因子-κB（NF-κB）细胞信号通路。本文综述了通过不同作用机制对肝纤维化具有活性的天然产物和草药，包括抗乙型和丙型肝炎病毒活性、抗炎、抑制细胞因子产生和核受体激活以及清除自由基。
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