Li Wen-Qing, Liu Wen-Hao, Qian Die, Liu Jia, Zhou Shi-Qiong, Zhang Lei, Peng Wei, Su Li, Zhang Hong
School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Front Pharmacol. 2022 Aug 23;13:962525. doi: 10.3389/fphar.2022.962525. eCollection 2022.
Hepatic fibrosis (HF) refers to the pathophysiological process of connective tissue dysplasia in the liver caused by various pathogenic factors. Nowadays, HF is becoming a severe threat to the health of human being. However, the drugs available for treating HF are limited. Currently, increasing natural agents derived from traditional Chinese medicines (TCMs) have been found to be beneficial for HF. A systemic literature search was conducted from PubMed, GeenMedical, Sci-Hub, CNKI, Google Scholar and Baidu Scholar, with the keywords of "traditional Chinese medicine," "herbal medicine," "natural agents," "liver diseases," and "hepatic fibrosis." So far, more than 76 natural monomers have been isolated and identified from the TCMs with inhibitory effect on HF, including alkaloids, flavones, quinones, terpenoids, saponins, phenylpropanoids, and polysaccharides, etc. The anti-hepatic fibrosis effects of these compounds include hepatoprotection, inhibition of hepatic stellate cells (HSC) activation, regulation of extracellular matrix (ECM) synthesis & secretion, regulation of autophagy, and antioxidant & anti-inflammation, etc. Natural compounds and extracts from TCMs are promising agents for the prevention and treatment of HF, and this review would be of great significance to development of novel drugs for treating HF.
肝纤维化（HF）是指由各种致病因素引起的肝脏结缔组织发育异常的病理生理过程。如今，肝纤维化正成为对人类健康的严重威胁。然而，可用于治疗肝纤维化的药物有限。目前，越来越多源自中药的天然药物已被发现对肝纤维化有益。通过PubMed、GeenMedical、Sci-Hub、中国知网、谷歌学术和百度学术进行了系统的文献检索，关键词为“中药”“草药”“天然药物”“肝脏疾病”和“肝纤维化”。到目前为止，已从对肝纤维化有抑制作用的中药中分离并鉴定出76种以上的天然单体，包括生物碱、黄酮类、醌类、萜类、皂苷、苯丙素类和多糖等。这些化合物的抗肝纤维化作用包括肝脏保护、抑制肝星状细胞（HSC）激活、调节细胞外基质（ECM）合成与分泌、调节自噬以及抗氧化和抗炎等。中药中的天然化合物和提取物是预防和治疗肝纤维化的有前景的药物，本综述对开发治疗肝纤维化的新药具有重要意义。
