Hospital of Chengdu, University of Traditional Chinese Medicine, Chengdu, China.
School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Front Endocrinol (Lausanne). 2022 Sep 7;13:990299. doi: 10.3389/fendo.2022.990299. eCollection 2022.
Obesity-insulin resistance-β-cells apoptosis" is an important trilogy of the pathogenesis of type 2 diabetes. With the global pandemic of obesity and diabetes, continuous research and development of new drugs focuses on the prevention of the pathological progress of these diseases. According to a recent study, the natural product kaempferol has excellent antidiabetic effects. Therefore, this review comprehensively summarized the frontier studies and pharmacological mechanisms of kaempferol in the treatment of diabetes. The successful research and development of kaempferol may yield a significant leap in the treatment of diabetes and its complications.
“肥胖-胰岛素抵抗-β 细胞凋亡”是 2 型糖尿病发病机制的重要三联征。随着肥胖和糖尿病在全球流行，新药的不断研发聚焦于这些疾病病理进程的预防。最近的一项研究表明，天然产物山柰酚具有优异的抗糖尿病作用。因此，本综述全面总结了山柰酚治疗糖尿病的前沿研究和药理学机制。山柰酚的成功研发可能会使糖尿病及其并发症的治疗取得重大飞跃。
