Donatelli I, Mancini G
Ann Ist Super Sanita. 1989;25(2):333-6.
Influenza subunit vaccines contain essentially only the envelope spike proteins, haemagglutinin (HA) and neuraminidase (NA). It is important to check the purity of each monovalent batch of these vaccines, in comparison with whole virus preparation. The authors have standardized a biochemical analysis for the laboratory control of this kind of vaccines, using PAGE test. All the vaccine manufactures are required to demonstrate, by this method, that the subunit vaccine contains HA and NA, with no more than trace amounts of internal proteins.
流感亚单位疫苗基本上只含有包膜刺突蛋白、血凝素（HA）和神经氨酸酶（NA）。与全病毒制剂相比，检查这些疫苗每一批单价疫苗的纯度很重要。作者使用聚丙烯酰胺凝胶电泳（PAGE）试验对这类疫苗的实验室控制进行了生化分析标准化。要求所有疫苗生产商通过这种方法证明亚单位疫苗含有HA和NA，且内部蛋白含量不超过痕量。
