Magurano Fabio, Zammarchi Lorenzo, Baggieri Melissa, Fortuna Claudia, Farese Alberto, Benedetti Eleonora, Fiorentini Cristiano, Rezza Giovanni, Nicoletti Loredana, Bartoloni Alessandro
1 Department of Infectious, Parasitic and Immune-Mediate Diseases, Istituto Superiore di Sanità , Rome, Italy .
Vector Borne Zoonotic Dis. 2015 Apr;15(4):258-60. doi: 10.1089/vbz.2014.1724.
Chikungunya virus (CHIKV) appeared for the first time in the Western Hemisphere--the French West Indies--in December of 2013. From there, the virus has spread to other Caribbean islands. Following the diagnosis of first autochthonous CHIKV cases in the Caribbean island of Saint Martin, a large outbreak is ongoing in the Americas. As of September 12, 2014, a total of 706,093 suspected and 9803 confirmed CHIKV cases have been reported in the Americas. This case study highlights the possibility of false-negative immunochromatographic CHIKV immunoglobulin M (IgM) tests and the need of confirmatory tests for suspected cases. Moreover, a greater spread of virus together with the presence of a mosquito vector (Aedes albopictus) enhances the risk of autochthonous transmission in Europe.
基孔肯雅病毒（CHIKV）于2013年12月首次出现在西半球——法属西印度群岛。此后，该病毒已传播至其他加勒比岛屿。在加勒比岛屿圣马丁岛确诊首例本土基孔肯雅病毒病例后，美洲正在发生大规模疫情。截至2014年9月12日，美洲共报告了706,093例疑似基孔肯雅病毒病例和9803例确诊病例。本案例研究强调了免疫层析法检测基孔肯雅病毒免疫球蛋白M（IgM）出现假阴性结果的可能性，以及对疑似病例进行确诊检测的必要性。此外，病毒的进一步传播以及蚊媒（白纹伊蚊）的存在增加了欧洲本土传播的风险。
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