IEEE J Biomed Health Inform. 2015 Jul;19(4):1321-30. doi: 10.1109/JBHI.2015.2423705. Epub 2015 Apr 17.
Since several years, the number of total hip arthroplasty revision surgeries is substantially growing. One of the main reasons for this procedure to become necessary is the loosening or damage of the prothesis, which is facilitated by bone necrosis at the implant-bone interface. Electrostimulation is one promising technique, which can accelerate the growth of bone cells and, therefore, enhance the anchorage of the implant to the bone. We present computational models of an electrostimulative total hip revision system to enhance bone regeneration. In this study, the influence of uncertainty in the conductivity of bone tissue on the electric field strength and the beneficial stimulation volume for an optimized electrode geometry and arrangement is investigated. The generalized polynomial chaos technique is used to quantify the uncertainty in the stimulation volumes with respect to the uncertain conductivity of cancellous bone, bone marrow, and bone substitute, which is used to fill defective areas. The results suggest that the overall beneficial stimulation areas are only slightly sensitive to the uncertainty in conductivity of bone tissue. However, in the proximity of tissue boundaries, larger uncertainties, especially in the transition between beneficial and understimulation areas, can be expected.
近年来，全髋关节翻修手术的数量显著增加。导致需要进行这种手术的主要原因之一是假体的松动或损坏，这是由于植入物-骨界面处的骨坏死而导致的。电刺激是一种很有前途的技术，可以加速骨细胞的生长，从而增强植入物与骨骼的固定。我们提出了一种电刺激全髋关节翻修系统的计算模型，以增强骨再生。在这项研究中，研究了骨组织电导率的不确定性对电场强度和优化电极几何形状和排列的有益刺激体积的影响。广义多项式混沌技术用于量化由于松质骨、骨髓和骨替代物的不确定电导率而导致刺激体积的不确定性，这些替代物用于填充缺陷区域。结果表明，整体有益刺激区域对骨组织电导率的不确定性只有轻微的敏感性。然而，在组织边界附近，可以预期会有更大的不确定性，特别是在有益刺激区域和刺激不足区域之间的过渡区域。
