Menteşe E, Yılmaz F, Karaali N, Ülker S, Kahveci B
Bioorg Khim. 2014 May-Jun;40(3):363-9.
This study presents a synthesis of new series of some benzimidazole, bisbenzimidazole and perimidine derivatives via microwave technique, which, leads to the good product yields and short reaction times. The structure of newly synthesized compounds was confirmed by 1H-NMR and 13C-NMR spectra. These compounds were screened for their lipase inhibition activity. Then, all compounds were evaluated with regard to pancreatic lipase activity, and some of the 2-substituted perimidines, bisperimidine and bisbenzimidazole derivatives showed lipase inhibition at various concentrations.
本研究通过微波技术合成了一系列新的苯并咪唑、双苯并咪唑和苝啶衍生物，该技术能带来良好的产物收率和较短的反应时间。新合成化合物的结构通过1H-NMR和13C-NMR光谱得以确证。对这些化合物进行了脂肪酶抑制活性筛选。然后，对所有化合物的胰脂肪酶活性进行了评估，部分2-取代苝啶、双苝啶和双苯并咪唑衍生物在不同浓度下表现出脂肪酶抑制作用。
