Silk Y N, Douglass H O, Nava H R, Driscoll D L, Tartarian G
Department of Surgical Oncology, Roswell Park Memorial Institute, Buffalo, New York 14263.
Ann Surg. 1989 Dec;210(6):751-7. doi: 10.1097/00000658-198912000-00010.
The median survival, from diagnosis, of patients with cancer of the gallbladder is 6 months. Our purpose in reviewing our experience was to identify factors, either in patient characteristics or treatment, that influence this statistic. In 22 years 71 cases of gallbladder carcinoma were referred to Roswell Park Memorial Institute in Buffalo, New York. Most had a cholecystectomy that revealed an unsuspected neoplasm, before referral. Mean age was 62 years and 75% were female. Symptoms, signs, and laboratory and imaging studies were uniformly unhelpful in determining the diagnosis. Early diagnosis at a stage amenable to surgical excision remains the sole salvation. Patients who receive chemotherapy did better than those who did not, but this is probably a reflection of patient selection. Newer treatment modalities are urgently needed.
胆囊癌患者自确诊起的中位生存期为6个月。我们回顾自身经验的目的是确定患者特征或治疗方面影响这一统计数据的因素。在22年里，纽约州布法罗市罗斯韦尔公园纪念研究所共收治了71例胆囊癌患者。大多数患者在转诊前接受了胆囊切除术，术后发现意外肿瘤。平均年龄为62岁，75%为女性。症状、体征以及实验室和影像学检查在确定诊断方面均无帮助。在适合手术切除的阶段进行早期诊断仍然是唯一的解决办法。接受化疗的患者比未接受化疗的患者情况更好，但这可能反映了患者选择的因素。迫切需要更新的治疗方式。
