Albores-Saavedra J, Alcántra-Vazquez A, Cruz-Ortiz H, Herrera-Goepfert R
Cancer. 1980 Mar 1;45(5):919-27. doi: 10.1002/1097-0142(19800301)45:5<919::aid-cncr2820450514>3.0.co;2-4.
In 200 consecutive cholecystectomy specimens excised for cholelithiasis or cholecystitis, 83% exhibited epithelial hyperplasia, 13.5%, atypical hyperplasia and 3.5%, carcinoma in situ. Carcinoma in situ was also observed in the mucosa adjacent to invasive carcinomas in 79% of 39 evaluable surgical cases and in 52.9% of 17 autopsy cases. Our findings suggest that a small number of hyperplasias of the gallbladder evolve toward atypical hyperplasia and that this progresses to in situ carcinoma which finally becomes invasive carcinoma. A simple cytologic technique is recommended for the diagnosis of atypical hyperplasia and carcinoma in situ in excised gallbladders. Preoperative identification of these two lesions in high-risk patients as well as comments on 156 invasive carcinomas are presented.
在200例因胆结石或胆囊炎而切除的胆囊标本中，83%表现为上皮增生，13.5%为非典型增生，3.5%为原位癌。在39例可评估的手术病例中的79%以及17例尸检病例中的52.9%中，在浸润性癌附近的黏膜中也观察到了原位癌。我们的研究结果表明，少数胆囊增生会发展为非典型增生，进而发展为原位癌，最终成为浸润性癌。建议采用一种简单的细胞学技术来诊断切除胆囊中的非典型增生和原位癌。本文还介绍了高危患者中这两种病变的术前识别以及对156例浸润性癌的评论。
