Satarova D E, Korchagin V B, Stepushkina V V, Makarova R A
Antibiot Khimioter. 1989 Aug;34(8):566-9.
A spectrophotometric method for assay of fusidic acid is described. The method is based on reaction with a reagent consisting of acetic anhydride and concentrated sulfuric acid. Mathematical processing of the results of the main substance determination in fusidic acid preparations showed that the error did not exceed 2 per cent. Procedures for spectrophotometric assay of fusidic acid in control of the processes of its biosynthesis, isolation and purification were developed. The procedures provided control of the technological process of fusidic acid production.
描述了一种测定夫西地酸的分光光度法。该方法基于与由乙酸酐和浓硫酸组成的试剂的反应。对夫西地酸制剂中主要物质测定结果的数学处理表明，误差不超过2%。制定了在夫西地酸生物合成、分离和纯化过程控制中进行分光光度测定的程序。这些程序实现了对夫西地酸生产工艺过程的控制。
