a Department of Pharmaceuticals, School of Pharmaceutical Sciences , UNESP - Univ Estadual Paulista , Campus de Araraquara, SP , Brazil.
Crit Rev Anal Chem. 2016 Jul 3;46(4):352-60. doi: 10.1080/10408347.2015.1084225. Epub 2015 Sep 4.
Fusidic acid, an antibiotic produced from the Fusidium coccineum fungus, belongs to the class of steroids, but has no corticosteroid effects. It is indicated for the treatment of infections caused by methicillin-resistant Staphylococcus aureus strains. The aim of this study was to search for the properties of fusidic acid published so far in the literature, as well as the methods developed for its determination in biological samples and pharmaceutical formulations. From the findings, we can conclude that fusidic acid has been used for decades and is indicated for the treatment of serious infections caused by Gram-positive microorganisms to this day. Furthermore, it is a hypoallergenic agent, has low toxicity, shows low resistance, and has no cross-resistance with other clinically used antibiotics. The analytical method of high-performance liquid chromatography has been widely used for determining fusidic acid, since it can reduce the cost and time of analysis, making it more viable for routine quality control in the pharmaceutical industry.
夫西地酸，一种从梭状芽胞杆菌属真菌中提取的抗生素，属于甾体类，但没有皮质类固醇的作用。它被用于治疗耐甲氧西林金黄色葡萄球菌菌株引起的感染。本研究旨在寻找迄今为止文献中发表的夫西地酸的特性，以及为其在生物样品和药物制剂中的测定而开发的方法。从研究结果可以得出结论，夫西地酸已经使用了几十年，至今仍被用于治疗由革兰氏阳性微生物引起的严重感染。此外，它是一种低致敏性药物，毒性低，耐药性低，与其他临床使用的抗生素无交叉耐药性。高效液相色谱法的分析方法已被广泛用于测定夫西地酸，因为它可以降低分析的成本和时间，使其更适合制药行业的常规质量控制。
