Aung Yin Yin May, Sowter Martin, Kenealy Timothy, Herman Josephine, Ekeroma Alec
Rarotonga Hospital, Te Marae Ora - Ministry of Health, Cook Islands.
N Z Med J. 2015 Apr 17;128(1412):21-8.
To describe current practices for screening for gestational diabetes mellitus in the Cook Islands and consider the implications of alternative screening strategies.
Eligible women had antenatal care from January 2009 to December 2012. A non-fasting 50 g glucose challenge between 24 and 28 weeks gestation (positive if 1-hour glucose greater than or equal to 7.8 mmol/L) was followed by a 75 g oral glucose tolerance test (gestational diabetes mellitus diagnosed if fasting glucose greater than or equal to 5.2 mmol/L or 2-hour glucose greater than or equal to 8.0 mmol/L; pregnancy impaired glucose tolerance if positive screen and negative diagnostic test).
Uptake of the screening programme rose from 49.0% to 99.6% by the end of the study period. 646 women had a glucose challenge; for 186/646 (28.8%) the challenge was positive; 183 had an oral glucose tolerance test; 89/646 (13.8%) had pregnancy impaired glucose tolerance; 94/646 (13.9%) had gestational diabetes mellitus. Median maternal weight gain was 6 kg (gestational diabetes mellitus) and 10 kg (normal glucose tolerance); caesarean section rates were 25% and 11% respectively; baby birthweights were not significantly different. 59 women with gestational diabetes mellitus had a post-natal glucose tolerance test at their 6-week check and 21 (35.6%) had diabetes confirmed.
The gestational diabetes mellitus screening programme has a high uptake and current management appears effective in reducing maternal and fetal weight gain. A proposed new screening programme is outlined.
描述库克群岛目前妊娠期糖尿病的筛查方法,并探讨替代筛查策略的影响。
选取2009年1月至2012年12月期间接受产前护理的符合条件的女性。在妊娠24至28周时进行非空腹50克葡萄糖耐量试验(如果1小时血糖大于或等于7.8毫摩尔/升则为阳性),之后进行75克口服葡萄糖耐量试验(如果空腹血糖大于或等于5.2毫摩尔/升或2小时血糖大于或等于8.0毫摩尔/升,则诊断为妊娠期糖尿病;如果筛查阳性但诊断试验阴性,则为妊娠糖耐量受损)。
到研究期结束时,筛查项目的参与率从49.0%上升至99.6%。646名女性进行了葡萄糖耐量试验;其中186/646(28.8%)试验结果为阳性;183人进行了口服葡萄糖耐量试验;89/646(13.8%)为妊娠糖耐量受损;94/646(13.9%)患有妊娠期糖尿病。孕妇体重增加的中位数在患有妊娠期糖尿病的女性中为6千克,糖耐量正常的女性中为10千克;剖宫产率分别为25%和11%;婴儿出生体重无显著差异。59名患有妊娠期糖尿病的女性在产后6周检查时进行了葡萄糖耐量试验,其中21人(35.6%)被确诊患有糖尿病。
妊娠期糖尿病筛查项目参与率高,目前的管理方法似乎能有效减少母婴体重增加。文中概述了一项提议的新筛查方案。