Teive Hélio A G, Arruda Walter O, Moro Adriana, Moscovich Mariana, Munhoz Renato P
Movement Disorders Unit, Neurology Service, Internal Medicine Department, Hospital de Clínicas, Federal University of Paraná, Curitiba, PR, Brazil.
Movement Disorders Unit, Neurology Service, Internal Medicine Department, Hospital de Clínicas, Federal University of Paraná, Curitiba, PR, Brazil.
Parkinsonism Relat Disord. 2015 Jun;21(6):640-3. doi: 10.1016/j.parkreldis.2015.04.001. Epub 2015 Apr 11.
Sporadic adult-onset ataxia encompasses a group of degenerative, non-hereditary disorders, including idiopathic adult-onset ataxia and the cerebellar form of multiple system atrophy. Our objective was to analyze the diagnosis at follow-up of 50 sporadic adult-onset ataxia patients.
Clinical and laboratory findings of 50 adult patients with sporadic adult-onset ataxia were analyzed. Diagnosis of probable REM sleep behavior disorder was based predominantly on clinically accepted criteria.
Multiple system atrophy was diagnosed in 48% of cases, the remaining 52% received a diagnosis of sporadic adult-onset ataxia. REM sleep behavior disorder was diagnosed in 46% of the patients. However, among patients with probable multiple system atrophy, the corresponding figure was 83.34% versus 11.53% among those with sporadic ataxia (p < 0.001).
REM sleep behavior disorder is an important aid to the differentiation of multiple system atrophy from sporadic adult-onset ataxia and its use for this purpose should be encouraged.
散发性成人起病共济失调包括一组退行性非遗传性疾病，包括特发性成人起病共济失调和多系统萎缩的小脑型。我们的目的是分析50例散发性成人起病共济失调患者随访时的诊断情况。
分析50例散发性成人起病共济失调成年患者的临床和实验室检查结果。可能的快速眼动睡眠行为障碍的诊断主要基于临床公认的标准。
48%的病例被诊断为多系统萎缩，其余52%被诊断为散发性成人起病共济失调。46%的患者被诊断为快速眼动睡眠行为障碍。然而，在可能患有多系统萎缩的患者中，这一比例为83.34%，而散发性共济失调患者中这一比例为11.53%（p<0.001）。
快速眼动睡眠行为障碍有助于多系统萎缩与散发性成人起病共济失调的鉴别，应鼓励将其用于这一目的。
