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癌症患者诊疗路径实施前后的诊断间隔——一项基于全科医生调查和登记处的三组癌症患者队列比较研究

Diagnostic intervals before and after implementation of cancer patient pathways - a GP survey and registry based comparison of three cohorts of cancer patients.

作者信息

Jensen Henry, Tørring Marie Louise, Olesen Frede, Overgaard Jens, Fenger-Grøn Morten, Vedsted Peter

机构信息

Research Centre for Cancer Diagnosis in Primary Care, Research Unit for General Practice, Department of Public Health, Aarhus University, Bartholins Allé 2, DK-8000, Aarhus C, Denmark.

Section for General Medical Practice, Department of Public Health, Aarhus University, Bartholins Allé 2, DK-8000, Aarhus C, Denmark.

出版信息

BMC Cancer. 2015 Apr 23;15:308. doi: 10.1186/s12885-015-1317-7.

Abstract

BACKGROUND

From 2008, Danish general practitioners could refer patients suspected of having cancer to standardised cancer patient pathways (CPPs). We aimed to compare the length of the diagnostic interval in 2010 with the length of the diagnostic interval before (2004/05) and during (2007/08) the implementation of CPPs in Denmark for all incident cancer patients who attended general practice prior to the cancer diagnosis.

METHODS

General practitioner questionnaires and register data on 12,558 patients were used to compare adjusted diagnostic interval across time by quantile regression.

RESULTS

The median diagnostic interval was 14 (95% CI: 11;16) days shorter during and 17 (95% CI: 15;19) days shorter after the implementation of CPPs than before. The diagnostic interval was 15 (95% CI: 12;17) days shorter for patients referred to a CPP in 2010 than during the implementation, whereas patients not referred to a CPP in 2010 had a 4 (95% CI: 1;7) days longer median diagnostic interval; the pattern was similar, but larger at the 75(th) and 90(th) percentiles.

CONCLUSION

The diagnostic interval was significantly lower after CPP implementation. Yet, patients not referred to a CPP in 2010 tended to have a longer diagnostic interval compared to during the implementation. CPPs may thus only seem to expedite the diagnostic process for some cancer patients.

摘要

背景

自2008年起,丹麦的全科医生可将疑似患有癌症的患者转至标准化癌症患者诊疗路径(CPPs)。我们旨在比较2010年所有在癌症诊断前曾就诊于全科诊所的新发癌症患者的诊断间隔时长与丹麦实施CPPs之前(2004/05年)及实施期间(2007/08年)的诊断间隔时长。

方法

使用全科医生调查问卷及12558名患者的登记数据,通过分位数回归比较不同时间点调整后的诊断间隔。

结果

实施CPPs期间的诊断间隔中位数比之前缩短了14天(95%置信区间:11;16),实施后缩短了17天(95%置信区间:15;19)。2010年被转至CPPs的患者的诊断间隔比实施期间缩短了15天(95%置信区间:12;17),而2010年未被转至CPPs的患者的诊断间隔中位数延长了4天(95%置信区间:1;7);在第75和第90百分位数处,模式相似但差异更大。

结论

实施CPPs后诊断间隔显著缩短。然而,2010年未被转至CPPs的患者与实施期间相比,诊断间隔往往更长。因此,CPPs可能仅对部分癌症患者加快了诊断进程。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f0a/4412104/422d3b319df1/12885_2015_1317_Fig1_HTML.jpg

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