Diagnostic Centre, Svendborg Hospital, Odense University Hospital, Svendborg, Denmark.
The Danish Cancer Society, Copenhagen, Denmark.
Br J Cancer. 2024 May;130(8):1304-1315. doi: 10.1038/s41416-024-02620-y. Epub 2024 Feb 26.
In 2011, as the first European country, Denmark introduced the non-organ-specific cancer patient pathway (CPP) for patients presenting with non-specific symptoms and signs of cancer (NSSC). The proportion of patients with cancer over time is unknown.
A retrospective cohort study of all patients with a NSSC-CPP investigational course in the province of Funen to the Diagnostic Centre in Svendborg from 2014 to 2021 was performed to evaluate the proportion of patients with cancer and serious disease over time.
A total of 6698 patients were referred to the NSSC-CPP of which 20.2% had cancer. While the crude referral rate increased from 114 per 100,000 people in 2014 and stabilised to around 214 in 2017-2021, the cancer detection rate of the total yearly new cancers in Funen diagnosed through the NSSC-CPP in DC Svendborg increased from 3 to 6%.
With now high and stable conversion and crude referral rates, the NSSC-CPP is one of the largest CPPs in Denmark as measured by the number of new cancer cases found. Similar urgent referral programmes in other countries might fill an unmet medical need for patients presenting with serious non-specific symptoms and signs of cancer in general practice.
2011 年，丹麦作为第一个欧洲国家，为出现非特异性癌症症状和体征（NSSC）的患者引入了非器官特异性癌症患者途径（CPP）。目前尚不清楚随着时间的推移，癌症患者的比例是多少。
对 2014 年至 2021 年期间，在菲英省向斯文堡诊断中心进行 NSSC-CPP 调查的所有患者进行了回顾性队列研究，以评估随时间推移癌症和严重疾病患者的比例。
共有 6698 名患者被转诊到 NSSC-CPP，其中 20.2%患有癌症。虽然粗转诊率从 2014 年的每 10 万人 114 例增加到 2017-2021 年的约 214 例，但通过 NSSC-CPP 在斯文堡 DC 诊断的菲英省每年新癌症的检出率从 3%增加到 6%。
目前高且稳定的转化率和粗转诊率使 NSSC-CPP 成为丹麦最大的 CPP 之一，按新发现癌症病例数衡量。其他国家类似的紧急转诊计划可能会满足一般实践中出现严重非特异性癌症症状和体征的患者的未满足的医疗需求。
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