3T和1.5T定量磁化率成像：一致性和可重复性评估
Quantitative Susceptibility Mapping at 3 T and 1.5 T: Evaluation of Consistency and Reproducibility.
作者信息
Hinoda Takuya, Fushimi Yasutaka, Okada Tomohisa, Fujimoto Koji, Liu Chunlei, Yamamoto Akira, Okada Tsutomu, Kido Aki, Togashi Kaori
机构信息
From the *Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan; and †Brain Imaging and Analysis Center and Department of Radiology, Duke University Medical Center, Durham, NC.
出版信息
Invest Radiol. 2015 Aug;50(8):522-30. doi: 10.1097/RLI.0000000000000159.
OBJECTIVES
The aim of this study was to assess the consistency and reproducibility of quantitative susceptibility mapping (QSM) at 3-T and 1.5-T magnetic resonance (MR) scanners.
MATERIALS AND METHODS
This study was approved by institutional ethics committee, and written informed consent was obtained. Twenty-two healthy volunteers underwent 2 examinations on different days. Each examination consisted of MR imaging on both 3-T and 1.5-T MR scanners. The data from both scanners and examination days were obtained, and QSM was calculated with STI Suite using 2 different algorithms--harmonic phase removal using laplacian operator (HARPERELLA) and a sophisticated harmonic artifact reduction for phase data (SHARP) method with a variable radius of the spherical kernel at the brain boundary (V-SHARP). We evaluated consistency of QSM between 3 T and 1.5 T and the reproducibility between the first and second examinations using 2-phase processing methods (HARPERELLA and V-SHARP).
RESULTS
Susceptibility values of regions of interests at 3 T were highly correlated with those at 1.5 T with good agreement (HARPERELLA, R2 = 0.838; V-SHARP, R2 = 0.898) (average difference, ±1.96 SD; HARPERELLA, -0.012 ± 0.046; V-SHARP, -0.002 ± 0.034). Reproducibility analysis demonstrated excellent correlation between the first and second examination at both 3 T and 1.5 T for both algorithms (HARPERELLA at 3 T, R2 = 0.921; 1.5 T, R2 = 0.891; V-SHARP at 3 T, R2 = 0.937; 1.5 T, R2 = 0.926). Bland-Altman analysis showed excellent reproducibility for HARPERELLA (3 T, -0.003 ± 0.032; 1.5 T, -0.003 ± 0.038) and V-SHARP (3 T, -0.003 ± 0.027; 1.5 T, -0.003 ± 0.029). Susceptibility values of these 2 algorithms were highly correlated with good agreement (3T, R2 = 0.961; 1.5 T, R = 0.931) (3 T, 0.009 ± 0.023; 1.5 T, -0.003 ± 0.049).
CONCLUSIONS
Quantitative susceptibility mapping with HARPERELLA and V-SHARP demonstrated good reproducibility at 3 T and 1.5 T, and QSM with V-SHARP demonstrated good consistency at 3 T and 1.5 T.
目的
本研究旨在评估3T和1.5T磁共振（MR）扫描仪上定量磁化率成像（QSM）的一致性和可重复性。
材料与方法
本研究经机构伦理委员会批准，并获得书面知情同意书。22名健康志愿者在不同日期接受了2次检查。每次检查包括在3T和1.5T MR扫描仪上进行MR成像。获取了两台扫描仪和两个检查日期的数据，并使用STI Suite通过两种不同算法计算QSM——使用拉普拉斯算子的谐波相位去除法（HARPERELLA）和用于相位数据的复杂谐波伪影减少法（SHARP），其中在脑边界处使用可变半径的球形内核（V-SHARP）。我们使用两种相位处理方法（HARPERELLA和V-SHARP）评估3T和1.5T之间QSM的一致性以及第一次和第二次检查之间的可重复性。
结果
3T时感兴趣区域的磁化率值与1.5T时的磁化率值高度相关，一致性良好（HARPERELLA，R2 = 0.838；V-SHARP，R2 = 0.898）（平均差异，±1.96 SD；HARPERELLA，-0.012 ± 0.046；V-SHARP，-0.002 ± 0.034）。可重复性分析表明，两种算法在3T和1.5T时第一次和第二次检查之间均具有极好的相关性（3T时的HARPERELLA，R2 = 0.921；1.5T时，R2 = 0.891；3T时的V-SHARP，R2 = 0.937；1.5T时，R2 = 0.926）。Bland-Altman分析显示HARPERELLA（3T，-0.003 ± 0.032；1.5T，-0.003 ± 0.038）和V-SHARP（3T，-0.003 ± 0.027；1.5T，-0.003 ± 0.029）具有极好的可重复性。这两种算法的磁化率值高度相关，一致性良好（3T，R2 = 0.961；1.5T，R = 0.931）（3T时，0.009 ± 0.023；1.5T时，-0.003 ± 0.049）。
结论
使用HARPERELLA和V-SHARP的定量磁化率成像在3T和1.5T时显示出良好的可重复性，使用V-SHARP的QSM在3T和1.5T时显示出良好的一致性。
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