Al Ghasham Nahlah S
Pathology Department, College of Medicine, Qassim University, Qassim, Saudi Arabia.
Int J Health Sci (Qassim). 2015 Jan;9(1):87-90.
Neutrophilic-chronic myelogenous leukemia (CML-N) is a rare chronic myelogenous leukemia (CML) variant characterized by BCR-ABL1 positive chronic neutrophilia. It has a BCR breakpoint on chromosome 22 between exons 17 and 20 in a region designated as micro-BCR. It is thought to have a more benign course than classical CML. This case report describes a 41-year-old Saudi woman diagnosed with CML-N. The peripheral blood and bone marrow picture for her were dominated by segmented neutrophils and fluorescent in situ hybridization was positive for BCR/ABL fusion of t(9;22). Our patient eventually required a stem cell transplant because of imatinib intolerance and bone marrow failure believed to be induced by nilotinib.
嗜中性粒细胞性慢性髓性白血病（CML-N）是一种罕见的慢性髓性白血病（CML）变体，其特征为BCR-ABL1阳性慢性嗜中性粒细胞增多。它在22号染色体上外显子17和20之间的一个被称为微BCR的区域有一个BCR断点。据认为，它的病程比经典CML更为良性。本病例报告描述了一名41岁被诊断为CML-N的沙特女性。她的外周血和骨髓检查结果以分叶核中性粒细胞为主，荧光原位杂交显示t(9;22)的BCR/ABL融合呈阳性。我们的患者最终因对伊马替尼不耐受以及据信由尼罗替尼诱导的骨髓衰竭而需要进行干细胞移植。
