AlGahtani Farjah H, Alshaman Leena, ElGohary Ghada, Aleem Aamer, AlQahtany Fatmah S
Division of Hematology/Oncology, Department of Medicine, College of Medicine, King Saud University, King Saud University Medical City, Riyadh, SAU.
Hematology and Oncology, Division of Hematology/oncology, College of Medicine, King Saud Medical City King Saud University, Riyadh, Saudi Arabia, and Departement of Adult Hematology/internal Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt, Cairo, EGY.
Cureus. 2023 Apr 6;15(4):e37201. doi: 10.7759/cureus.37201. eCollection 2023 Apr.
Chronic myelogenous leukemia, or CML, is another name for chronic myeloid leukemia (CML), a cancer type that starts in certain bone marrow blood-forming cells. The primary initiator of granulocytic proliferation in CML, a myeloproliferative malignancy, is the BCR-ABL1 fusion protein or Philadelphia chromosome. CML is classified into three stages: chronic, accelerated, and blast. It has been widely recognized that the likelihood of developing CML varies by gender, geography, and age. In the chronic phase of CML (CML-CP), bleeding is a rare sign since the thrombocyte and coagulation functions are still adequate. Uncertainties exist regarding the CML bleeding mechanism. We report four cases of CML-CP in adult patients. The majority of these patients had CML and had idiopathic spontaneous bleeding in multiple locations.
慢性髓性白血病（CML）是慢性粒细胞白血病的另一个名称，它是一种起源于特定骨髓造血细胞的癌症类型。慢性粒细胞白血病是一种骨髓增殖性恶性肿瘤，其粒细胞增殖的主要引发因素是BCR-ABL1融合蛋白或费城染色体。慢性粒细胞白血病分为三个阶段：慢性期、加速期和急变期。人们普遍认识到，患慢性粒细胞白血病的可能性因性别、地理位置和年龄而异。在慢性粒细胞白血病的慢性期（CML-CP），由于血小板和凝血功能仍然正常，出血是一种罕见的症状。关于慢性粒细胞白血病的出血机制存在不确定性。我们报告了4例成年慢性粒细胞白血病慢性期患者。这些患者大多数患有慢性粒细胞白血病，并在多个部位出现特发性自发性出血。
