视网膜中央静脉阻塞与正常眼的眼前节光学相干断层扫描参数比较：原发性闭角型青光眼是视网膜中央静脉阻塞的危险因素吗？

COMPARISON OF ANTERIOR SEGMENT OPTICAL COHERENCE TOMOGRAPHY PARAMETERS BETWEEN CENTRAL RETINAL VEIN OCCLUSION AND NORMAL EYES: Is Primary Angle Closure a Risk Factor for Central Retinal Vein Occlusion?

作者信息

Mohammadi Massood, Bazvand Fatemeh, Makateb Ali, Eslami Yadollah, Jabbarvand Behrooz Mahmood, Fakhraie Ghasem, Zarei Reza, Moghimi Sasan

机构信息

Department of Ophthalmology, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

Retina. 2015 Sep;35(9):1795-9. doi: 10.1097/IAE.0000000000000549.

DOI:10.1097/IAE.0000000000000549

PMID:25901836

Abstract

PURPOSE

To compare anterior segment parameters in patients with central retinal vein occlusion (CRVO) with normal control subjects by anterior segment optical coherence tomography (AS-OCT).

METHODS

In this coss-sectional case-control study, 42 eyes from 21 patients with unilateral CRVO and 21 eyes from 21 age- and sex-matched healthy control subjects were recruited. Study eyes were divided into three groups: involved eyes of CRVO patients (CRVO eyes), fellow eyes of CRVO patients (fellow eyes), and control eyes. Complete ocular examination and AS-OCT were performed for each eye. The AS-OCT parameters (anterior chamber depth, scleral spur angle, angle opening distance [AOD] at 500 and 750 μm from scleral spur [AOD500 and 750] and trabecular-iris space area [TISA] at 500 and 750 μm from scleral spur [TISA500 and 750]) and the rate of narrow angles (based on gonioscopy) in CRVO and fellow eyes were compared with control eyes.

RESULTS

The mean (SD) age of the patients and the control group were 60.09 (9.43) and 59.52 (6.66), respectively. The mean intraocular pressure in both eyes of the patients was significantly higher than the control eyes (P < 0.05). All AS-OCT parameters were significantly different among the three groups (P < 0.05). Comparing with the control eyes, CRVO eyes had shallower anterior chamber depth (2.53 vs. 2.85 mm; P = 0.002) and narrower AS-OCT angle parameters (scleral spur angle, AOD500 and 750, TISA500 and 750). Fellow eyes had also shallower anterior chamber depth (2.56 vs. 2.85 mm; P = 0.005) than control eyes and smaller scleral spur angle, AOD500 and AOD750. Five CRVO patients (23.8%) were diagnosed with narrow angles in both eyes based on gonioscopy, whereas no eye in the control group had narrow angles (P = 0.05).

CONCLUSION

Imaging with AS-OCT showed that CRVO patients had shallower anterior chamber depth and narrower angle parameters in both eyes in comparison with control eyes. Furthermore, CRVO patients had higher rates of narrow angles on gonioscopic examination.

摘要

目的

通过眼前节光学相干断层扫描（AS-OCT）比较中心性视网膜静脉阻塞（CRVO）患者与正常对照者的眼前节参数。

方法

在这项横断面病例对照研究中，招募了21例单侧CRVO患者的42只眼以及21例年龄和性别匹配的健康对照者的21只眼。研究眼分为三组：CRVO患者的患眼（CRVO眼）、CRVO患者的对侧眼（对侧眼）和对照眼。对每只眼进行全面的眼部检查和AS-OCT检查。比较CRVO眼和对侧眼中的AS-OCT参数（前房深度、巩膜突角度、距巩膜突500和750μm处的房角开放距离[AOD500和750]以及距巩膜突500和750μm处的小梁-虹膜空间面积[TISA500和750]）以及窄角发生率（基于房角镜检查）与对照眼的差异。

结果

患者组和对照组的平均（标准差）年龄分别为60.09（9.43）岁和59.52（6.66）岁。患者双眼的平均眼压显著高于对照眼（P<0.05）。三组之间所有AS-OCT参数均有显著差异（P<0.05）。与对照眼相比，CRVO眼的前房深度较浅（2.53 vs. 2.85mm；P=0.002），AS-OCT角度参数（巩膜突角度、AOD500和750、TISA500和750）较窄。对侧眼的前房深度也比对照眼浅（2.56 vs. 2.85mm；P=0.005），巩膜突角度、AOD500和AOD750较小。根据房角镜检查，5例CRVO患者（23.8%）双眼被诊断为窄角，而对照组中无眼为窄角（P=0.05）。