Mansouri Mohammadreza, Ramezani Farshid, Moghimi Sasan, Tabatabaie Ali, Abdi Fatemeh, He Mingguang, Lin Shan C
Farabi Eye Hospital, Tehran University of Medical Science, Tehran, Iran.
Farabi Eye Hospital, Tehran University of Medical Science, Tehran, Iran Koret Vision Center, University of California, San Francisco Medical School, San Francisco, California, United States.
Invest Ophthalmol Vis Sci. 2014 Oct 21;55(11):7403-9. doi: 10.1167/iovs.14-14748.
To describe anterior segment optical coherence tomography (AS-OCT) parameters in phacomorphic angle closure eyes, mature cataract eyes, and their fellow eyes, and identify those parameters that could be used to differentiate phacomorphic angle closure eyes from those with mature cataract and no phacomorphic angle closure.
In this cross-sectional study, a total of 33 phacomorphic angle closure subjects and 34 control patients with unilateral mature cataracts were enrolled. All patients underwent AS-OCT imaging and A-scan biometry of both eyes. Anterior chamber depth (ACD), anterior chamber area (ACA), iris thickness, iris curvature, lens vault (LV), and angle parameters, including angle opening distance (AOD750) and trabecular-iris space area (TISA750), were measured in qualified images using customized software and compared among eyes with phacomorphic angle closure, mature cataract eyes, and their fellow eyes.
There was no significant difference in axial length among the four groups. Phacomorphic angle closure had the smallest angle (AOD750, TISA750) and anterior chamber parameters (ACD, ACA, anterior chamber width) and the greatest LV among the groups. This pattern was similar when comparing fellow eyes of mature cataract patients and fellow eyes of phacomorphic angle closure. Anterior chamber area less than 18.62 mm(2), ACD less than 2.60 mm, LV greater than 532.0 μm, and AOD750 less than 0.218 mm had the highest odds ratios (ORs) for distinguishing fellow eyes of phacomorphic angle closure versus fellow eyes of mature cataracts, with OR values of 9.90, 8.31, 7.91, and 7.91, respectively. Logistic regression showed that ACA less than 18.62 was the major parameter associated with fellow eyes of phacomorphic angle closure (OR = 10.96, P < 0.001).
Anterior chamber depth, ACA, AOD750, and LV are powerful indicators in differentiating phacomorphic angle closure eyes from those with mature cataract and their fellow eyes.
描述晶状体膨胀性房角关闭眼、成熟期白内障眼及其对侧眼的眼前节光学相干断层扫描（AS-OCT）参数，并确定可用于区分晶状体膨胀性房角关闭眼与成熟期白内障且无晶状体膨胀性房角关闭眼的参数。
在这项横断面研究中，共纳入33例晶状体膨胀性房角关闭患者和34例单侧成熟期白内障对照患者。所有患者均接受双眼的AS-OCT成像和A超生物测量。使用定制软件在合格图像中测量前房深度（ACD）、前房面积（ACA）、虹膜厚度、虹膜曲率、晶状体拱高（LV）以及房角参数，包括房角开放距离（AOD750）和小梁-虹膜空间面积（TISA750），并在晶状体膨胀性房角关闭眼、成熟期白内障眼及其对侧眼之间进行比较。
四组之间的眼轴长度无显著差异。晶状体膨胀性房角关闭组的房角（AOD750、TISA750）和前房参数（ACD、ACA、前房宽度）最小，晶状体拱高最大。在比较成熟期白内障患者的对侧眼和晶状体膨胀性房角关闭患者对侧眼时，这种模式相似。前房面积小于18.62mm²、ACD小于2.60mm、LV大于532.0μm以及AOD750小于0.218mm，在区分晶状体膨胀性房角关闭对侧眼与成熟期白内障对侧眼时具有最高的优势比（OR），OR值分别为9.90、8.31、7.91和7.91。逻辑回归显示，ACA小于18.62是与晶状体膨胀性房角关闭对侧眼相关的主要参数（OR = 10.96，P < 0.001）。
前房深度、ACA、AOD750和LV是区分晶状体膨胀性房角关闭眼与成熟期白内障眼及其对侧眼的有力指标。
