van der Molen Nathalie C, Tiemersma-Wegman Theodora D, Fañanás-Mastral Martín, Feringa Ben L
Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG, Groningen, The Netherlands.
J Org Chem. 2015 May 15;80(10):4981-4. doi: 10.1021/acs.joc.5b00371. Epub 2015 May 1.
A highly efficient method for the copper-catalyzed asymmetric allylic alkylation of ortho-substituted cinnamyl bromides with Grignard reagents is reported. The use of a catalytic system comprising CuBr·SMe2 and TaniaPhos as chiral ligands gives rise to a range of branched products with excellent regio- and enantioselectivity.
报道了一种高效的铜催化邻位取代肉桂基溴与格氏试剂的不对称烯丙基烷基化方法。使用由CuBr·SMe₂和TaniaPhos作为手性配体组成的催化体系,可得到一系列具有优异区域和对映选择性的支链产物。