Schwartz A N, Graham M M, Ferency G F, Miura R S
Department of Radiology and Nuclear Medicine, Seattle Veterans Administration Medical Center, WA 98108.
J Nucl Med. 1989 Apr;30(4):466-73.
Radioisotope penile plethysmography is a nuclear medicine technique which assists in the evaluation of patients with erectile dysfunction. This technique attempts to noninvasively quantitate penile corpora cavernosal blood flow during early penile tumescence using technetium-99m-labeled red blood cells. Penile images and counts were acquired in a steady-state blood-pool phase prior to and after the administration of intracorporal papaverine. Penile counts, images, and time-activity curves were computer analyzed in order to determine peak corporal flow and volume changes. Peak corporal flow rates were compared to arterial integrity (determined by angiography) and venosinusoidal corporal leak (determined by cavernosometry). Peak corporal flow correlated well with arterial integrity (r = 0.91) but did not correlate with venosinusoidal leak parameters (r = 0.01). This report focuses on the methodology and the assumptions which form the foundation of this technique. The strong correlation of peak corporal flow and angiography suggests that radioisotope penile plethysmography could prove useful in the evaluation of arterial inflow disorders in patients with erectile dysfunction.
放射性同位素阴茎体积描记术是一种核医学技术，可辅助评估勃起功能障碍患者。该技术试图使用锝-99m标记的红细胞在阴茎早期肿胀期间无创定量阴茎海绵体血流。在注射海绵体内罂粟碱之前和之后的稳态血池期采集阴茎图像和计数。对阴茎计数、图像和时间-活性曲线进行计算机分析，以确定峰值海绵体血流和体积变化。将峰值海绵体血流速率与动脉完整性（通过血管造影确定）和静脉窦海绵体漏（通过海绵体测压确定）进行比较。峰值海绵体血流与动脉完整性相关性良好（r = 0.91），但与静脉窦漏参数无相关性（r = 0.01）。本报告重点关注构成该技术基础的方法和假设。峰值海绵体血流与血管造影的强相关性表明，放射性同位素阴茎体积描记术在评估勃起功能障碍患者的动脉流入障碍方面可能有用。
