Miraldi F, Nelson A D, Jones W T, Thompson S, Kursh E D
Department of Radiology, CWRU, School of Medicine, Cleveland, Ohio.
J Nucl Med. 1992 Jan;33(1):41-6.
A technique is described for concomitant study of both arterial and venous penile blood flow during tumescence. Dual-isotope acquisition is started after labeling red cells in vivo with 99mTc. Xenon-133 in saline is then injected into the corpus cavernosum followed with vasoactive drugs to induce an erection. The resulting xenon and technetium time-activity curves are inputs for a one-compartment model. In 14 subjects, the average peak arterial flow rate (PAF) for normal males was calculated as 13.0 +/- 1.28 ml/min (avg +/- s.d.) compared to 16.1 +/- 5.14 and 5.02 +/- 1.78 ml/min for patients with venous leak (VL) or arterial insufficiency (AI), respectively. Peak venous flows (PVF) were 4.25 +/- 1.17, 12.1 +/- 3.75, and 3.78 +/- 1.00 ml/min for normal, VL and AL respectively. Al patients have significantly lower PAF than normal (p = 0.002) or VL patients (p = 0.018), and VL patients had significantly higher PVF than normal (p = 0.012) or Al (p = 0.018). The technique may be helpful in the study of impotence.
本文描述了一种在阴茎勃起时同时研究动脉和静脉血流的技术。在用99mTc对体内红细胞进行标记后开始双同位素采集。然后将盐水中的氙-133注入海绵体，接着使用血管活性药物诱导勃起。所得的氙和锝时间-活性曲线作为单室模型的输入。在14名受试者中，正常男性的平均峰值动脉血流率（PAF）计算为13.0±1.28毫升/分钟（平均值±标准差），而静脉漏（VL）或动脉供血不足（AI）患者的分别为16.1±5.14和5.02±1.78毫升/分钟。正常、VL和AI患者的峰值静脉血流（PVF）分别为4.25±1.17、12.1±3.75和3.78±1.00毫升/分钟。AI患者的PAF显著低于正常（p = 0.002）或VL患者（p = 0.018），VL患者的PVF显著高于正常（p = 0.012）或AI患者（p = 0.018）。该技术可能有助于阳痿的研究。
