Niki Toshiyuki, Soeki Takeshi, Yamaguchi Koji, Taketani Yoshio, Yagi Shusuke, Iwase Takashi, Yamada Hirotsugu, Wakatsuki Tetsuzo, Shimabukuro Michio, Sata Masataka
Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, 2. Department of Cardiovascular Medicine, Shikoku Medical Center for Children and Adults, Zentsuji, Japan.
Int Heart J. 2015 May 13;56(3):269-72. doi: 10.1536/ihj.14-300. Epub 2015 Apr 23.
Several studies have shown that various chemokines are more highly expressed in atherosclerotic plaques than in normal vessel walls. In the present study, we investigated the relationship between coronary atherosclerosis and noteworthy chemokines, including interferon-inducible protein of 10 kD (IP-10); monocyte chemoattractant protein 1 (MCP-1); regulated on activation, normal T-cell expressed and secreted (RANTES); and high-sensitivity C-reactive protein (hsCRP), an established marker of atherosclerotic disease. We studied 28 patients who underwent coronary angiography because of suspected coronary artery disease (CAD). CAD was defined as stenosis of more than 50% of the vessel diameter on coronary angiograms. Blood samples were obtained both from the aorta and the coronary sinus (CS) just before coronary angiography. Relative to CAD (-) patients, those who were CAD (+) tended to have higher plasma concentrations of IP-10 in the aorta, as well as significantly higher transcoronary concentration gradients of circulating IP-10. There were no significant differences between the two groups in aortic plasma concentrations or transcoronary concentration gradients of MCP-1, RANTES, and hsCRP. Furthermore, both the aortic plasma concentrations and transcoronary concentration gradients of IP-10 correlated with the Gensini score (r = 0.58 and r = 0.63, respectively, P < 0.01), while the plasma MCP-1, RANTES, and serum hsCRP concentrations did not. This study suggests that IP-10 is a good surrogate marker of coronary atherosclerosis.
多项研究表明，多种趋化因子在动脉粥样硬化斑块中的表达高于正常血管壁。在本研究中，我们调查了冠状动脉粥样硬化与几种重要趋化因子之间的关系，这些趋化因子包括10kD干扰素诱导蛋白（IP-10）、单核细胞趋化蛋白1（MCP-1）、活化正常T细胞表达和分泌因子（RANTES）以及高敏C反应蛋白（hsCRP），后者是动脉粥样硬化疾病的既定标志物。我们研究了28例因疑似冠状动脉疾病（CAD）而接受冠状动脉造影的患者。CAD定义为冠状动脉造影显示血管直径狭窄超过50%。在冠状动脉造影前，从主动脉和冠状窦（CS）采集血样。相对于CAD（-）患者，CAD（+）患者主动脉中IP-10的血浆浓度往往更高，循环IP-10的跨冠状动脉浓度梯度也显著更高。两组在主动脉血浆浓度或MCP-1、RANTES和hsCRP的跨冠状动脉浓度梯度方面无显著差异。此外，IP-10的主动脉血浆浓度和跨冠状动脉浓度梯度均与Gensini评分相关（分别为r = 0.58和r = 0.63，P < 0.01），而血浆MCP-1、RANTES和血清hsCRP浓度则无此相关性。本研究表明，IP-10是冠状动脉粥样硬化的良好替代标志物。
