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A novel cardioprotective mechanism of exogenous nitric oxide: inhibition of Rho-associated kinase activity.

作者信息

Tanaka Atsushi, Node Koichi

机构信息

Department of Cardiovascular Medicine, Saga University, Saga, Japan.

出版信息

Hypertens Res. 2015 Jul;38(7):461-2. doi: 10.1038/hr.2015.61. Epub 2015 Apr 23.

DOI:10.1038/hr.2015.61
PMID:25902902
Abstract
摘要

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本文引用的文献

1
Exogenous nitric oxide inhibits Rho-associated kinase activity in patients with angina pectoris: a randomized controlled trial.外源性一氧化氮抑制心绞痛患者 Rho 相关激酶活性：一项随机对照试验。
Hypertens Res. 2015 Jul;38(7):485-90. doi: 10.1038/hr.2015.24. Epub 2015 Mar 5.
2
Critical role of exogenous nitric oxide in ROCK activity in vascular smooth muscle cells.外源性一氧化氮在血管平滑肌细胞ROCK活性中的关键作用。
PLoS One. 2014 Oct 3;9(10):e109017. doi: 10.1371/journal.pone.0109017. eCollection 2014.
3
Resveratrol prevents AngII-induced hypertension via AMPK activation and RhoA/ROCK suppression in mice.
白藜芦醇通过激活 AMPK 和抑制 RhoA/ROCK 预防 AngII 诱导的高血压。
Hypertens Res. 2014 Sep;37(9):803-10. doi: 10.1038/hr.2014.90. Epub 2014 Jun 26.
4
Carperitide induces coronary vasodilation and limits infarct size in canine ischemic hearts: role of NO.卡贝缩宫肽诱导犬缺血心脏冠脉扩张并限制梗死面积：NO 的作用。
Hypertens Res. 2014 Aug;37(8):716-23. doi: 10.1038/hr.2014.70. Epub 2014 Apr 3.
5
Rho/Rho-associated coiled-coil forming kinase pathway as therapeutic targets for statins in atherosclerosis.Rho/Rho 相关卷曲螺旋形成激酶通路作为他汀类药物在动脉粥样硬化中的治疗靶点。
Antioxid Redox Signal. 2014 Mar 10;20(8):1251-67. doi: 10.1089/ars.2013.5524. Epub 2013 Sep 24.
6
Enhanced Rho-kinase activity in circulating neutrophils of patients with vasospastic angina: a possible biomarker for diagnosis and disease activity assessment.痉挛性心绞痛患者循环中性粒细胞中 Rho 激酶活性增强：一种可能的诊断和疾病活动评估的生物标志物。
J Am Coll Cardiol. 2011 Sep 13;58(12):1231-7. doi: 10.1016/j.jacc.2011.05.046.
7
Measurement of Rho-associated kinase (ROCK) activity in humans: validity of leukocyte p-MBS/t-MBS in comparison with vascular response to fasudil.人 Rho 相关激酶（ROCK）活性的测定：白细胞 p-MBS/t-MBS 与法舒地尔诱导的血管反应的比较的有效性。
Atherosclerosis. 2011 Jan;214(1):117-21. doi: 10.1016/j.atherosclerosis.2010.10.005. Epub 2010 Oct 12.
8
Rho-kinase is an important therapeutic target in cardiovascular medicine.Rho激酶是心血管医学中的一个重要治疗靶点。
Arterioscler Thromb Vasc Biol. 2005 Sep;25(9):1767-75. doi: 10.1161/01.ATV.0000176193.83629.c8. Epub 2005 Jul 7.
9
Rocks: multifunctional kinases in cell behaviour.ROCKs：细胞行为中的多功能激酶
Nat Rev Mol Cell Biol. 2003 Jun;4(6):446-56. doi: 10.1038/nrm1128.
10
Rho-kinase inhibition with intracoronary fasudil prevents myocardial ischemia in patients with coronary microvascular spasm.冠状动脉内注射法舒地尔抑制 Rho 激酶可预防冠状动脉微血管痉挛患者的心肌缺血。
J Am Coll Cardiol. 2003 Jan 1;41(1):15-9. doi: 10.1016/s0735-1097(02)02632-3.