Medical Thrombosis and Haemophilia Treatment Center, Duisburg, Germany.
Thromb Res. 2015 Feb;135 Suppl 1:S34-7. doi: 10.1016/S0049-3848(15)50438-6. Epub 2015 Feb 9.
In women, von Willebrand disease (VWD) is the most common inherited bleeding disorder. Objectively, it is defined as bleeding that lasts for more than seven days or results in the loss of more than 80 mL of blood per menstrual cycle. The prevalence of menorrhagia in a woman with a bleeding disorder ranges from 32 to 100%. Postpartum hemorrhage (PPH) remains one of the leading causes of maternal morbidity and mortality worldwide. A treatment algorithm for severe persistent PPH was subsequently developed. These include mechanical or surgical maneuvers, i.e., intrauterine balloon tamponade or hemostatic brace sutures with hysterectomy as the final surgical option for uncontrollable PPH. Pharmacologic options include hemostatic agents (tranexamic acid), with timely transfusion of blood and plasma products playing an important role in persistent and severe PPH.
在女性中，血管性血友病（von Willebrand disease，VWD）是最常见的遗传性出血性疾病。从客观上讲，它被定义为出血持续超过 7 天或每个月经周期失血超过 80 毫升。患有出血性疾病的女性月经过多的患病率为 32%至 100%。产后出血（postpartum hemorrhage，PPH）仍然是全球产妇发病率和死亡率的主要原因之一。随后制定了一种用于严重持续性 PPH 的治疗算法。这些方法包括机械或手术操作，即宫内球囊填塞或止血带缝合术，对于无法控制的 PPH 则作为最后的手术选择。药物治疗选择包括止血剂（氨甲环酸），及时输注血液和血浆制品在持续性和严重 PPH 中起着重要作用。
