Botoseneanu Anda, Bennett Joan M, Nyquist Linda, Shinkai Shoji, Fujiwara Yoshinori, Yoshida Hiroto, Aiello Allison, Cigolle Christine T, Liang Jersey
Yale University, New Haven, CT, USA University of Michigan-Dearborn, USA
University of Michigan, Ann Arbor, USA.
J Aging Health. 2015 Oct;27(7):1123-46. doi: 10.1177/0898264315577587. Epub 2015 Apr 22.
To examine the association between cardiometabolic risk (percent body fat [BF%], triglycerides [TG], high-density lipoprotein [HDL]-cholesterol, hemoglobin A1c [HbA1c]), socio-psychological factors (education and self-rated health [SRH]), and trajectories of grip strength (GS) in older adults.
Longitudinal 8-year data from 1,381 Japanese adults aged 65 years or above were analyzed using hierarchical linear models, stratified according to gender.
GS declined following a linear trajectory. In both genders, higher BF% was associated with weaker GS, but not with the rate of decline. GS trajectory did not correlate with baseline TG, HDL-C, or HbA1c. Cardiometabolic factors mediated educational differences in GS intercept in both genders. In women, better SRH predicted stronger GS. The effect of SRH was robust to adjustments for cardiometabolic risk.
In older adults, GS and its rate of decline are selectively associated with both cardiometabolic risk and socio-psychological characteristics. Cardiometabolic risk mediates educational disparities in GS but not differences in subjective assessments of health.
研究老年人心脏代谢风险（体脂百分比[BF%]、甘油三酯[TG]、高密度脂蛋白[HDL]-胆固醇、糖化血红蛋白[HbA1c]）、社会心理因素（教育程度和自评健康状况[SRH]）与握力（GS）轨迹之间的关联。
使用分层线性模型分析了1381名65岁及以上日本成年人的8年纵向数据，并按性别分层。
GS呈线性轨迹下降。在男女两性中，较高的BF%与较弱的GS相关，但与下降速率无关。GS轨迹与基线TG、HDL-C或HbA1c无关。心脏代谢因素介导了男女两性在GS截距上的教育差异。在女性中，较好的SRH预示着较强的GS。SRH的影响在调整心脏代谢风险后依然稳健。
在老年人中，GS及其下降速率与心脏代谢风险和社会心理特征均存在选择性关联。心脏代谢风险介导了GS方面的教育差异，但未介导健康主观评估方面的差异。
