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Personalized medicine, endotypes, and intensive care medicine.

作者信息

Wong Hector R

机构信息

Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center and Cincinnati Children's Research Foundation, Cincinnati, OH, USA,

出版信息

Intensive Care Med. 2015 Jun;41(6):1138-40. doi: 10.1007/s00134-015-3812-3. Epub 2015 Apr 24.

DOI:10.1007/s00134-015-3812-3
PMID:25904185
Abstract
摘要

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Intensive Care Med. 2015 May;41(5):814-22. doi: 10.1007/s00134-015-3764-7. Epub 2015 Apr 8.
2
A new initiative on precision medicine.一项关于精准医学的新倡议。
N Engl J Med. 2015 Feb 26;372(9):793-5. doi: 10.1056/NEJMp1500523. Epub 2015 Jan 30.
3
Developing a clinically feasible personalized medicine approach to pediatric septic shock.开发一种针对儿童脓毒性休克的临床可行的个性化医疗方法。
Crit Care. 2017 Apr 3;21(1):79. doi: 10.1186/s13054-017-1653-x.
4
Visit to intensive care of 2050.2050年的重症监护探访。
Intensive Care Med. 2017 Jan;43(1):97-100. doi: 10.1007/s00134-016-4525-y. Epub 2016 Aug 31.
5
Distinct Myocardial Mechanisms Underlie Cardiac Dysfunction in Endotoxemic Male and Female Mice.内毒素血症雄性和雌性小鼠心脏功能障碍背后存在不同的心肌机制。
Shock. 2016 Dec;46(6):713-722. doi: 10.1097/SHK.0000000000000679.
6
Sepsis without SIRS is still sepsis.无全身炎症反应综合征的脓毒症仍为脓毒症。
Ann Transl Med. 2015 Nov;3(19):294. doi: 10.3978/j.issn.2305-5839.2015.11.13.
7
Mortality Prediction Model of Septic Shock Patients Based on Routinely Recorded Data.基于常规记录数据的脓毒性休克患者死亡率预测模型
Comput Math Methods Med. 2015;2015:761435. doi: 10.1155/2015/761435. Epub 2015 Oct 18.
Am J Respir Crit Care Med. 2015 Feb 1;191(3):309-15. doi: 10.1164/rccm.201410-1864OC.
4
A functional synonymous coding variant in the IL1RN gene is associated with survival in septic shock.白细胞介素 1 受体拮抗剂基因中的一个功能性同义编码变异与脓毒性休克患者的生存相关。
Am J Respir Crit Care Med. 2014 Sep 15;190(6):656-64. doi: 10.1164/rccm.201403-0586OC.
5
Gene expression profiling in sepsis: timing, tissue, and translational considerations.脓毒症中的基因表达谱分析：时机、组织及转化医学考量
Trends Mol Med. 2014 Apr;20(4):204-13. doi: 10.1016/j.molmed.2014.01.006. Epub 2014 Feb 15.
6
A multibiomarker-based outcome risk stratification model for adult septic shock*.基于多生物标志物的成人脓毒性休克结局风险分层模型*。
Crit Care Med. 2014 Apr;42(4):781-9. doi: 10.1097/CCM.0000000000000106.
7
Treating inflammation by blocking interleukin-1 in humans.通过阻断白细胞介素-1 治疗人类炎症。
Semin Immunol. 2013 Dec 15;25(6):469-84. doi: 10.1016/j.smim.2013.10.008. Epub 2013 Nov 23.
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IL1RN coding variant is associated with lower risk of acute respiratory distress syndrome and increased plasma IL-1 receptor antagonist.IL1RN 编码变异与急性呼吸窘迫综合征风险降低相关，并增加血浆 IL-1 受体拮抗剂。
Am J Respir Crit Care Med. 2013 May 1;187(9):950-9. doi: 10.1164/rccm.201208-1501OC.
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Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012.拯救脓毒症运动：严重脓毒症和脓毒性休克管理国际指南，2012 年。
Intensive Care Med. 2013 Feb;39(2):165-228. doi: 10.1007/s00134-012-2769-8. Epub 2013 Jan 30.
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