肥胖中的内分泌变化

Endocrine Changes in Obesity

作者信息

Ylli Dorina, Sidhu Sharleen, Parikh Tanvi, Burman Kenneth D.

机构信息

Division of Endocrinology, MedStar Washington Hospital Center, 110 Irving St NW, Washington DC, 20010, USA, University of Medicine Tirana, 371 Dibra St, 1005, Tirana, Albania

Medical Director Endocrinology, Marin Health Medical Network, Medical Director, Braden Diabetes Center, 900 South Eliseo Drive, Suite 201, Greenbrae, CA 94904.

PMID:25905281

Abstract

Obesity can be associated with several endocrine alterations arising from changes in the hypothalamic-pituitary hormones axes. These include hypothyroidism, Cushing’s disease, hypogonadism, and growth hormone deficiency. Besides its role in energy storage, adipose tissue has many other important functions that can be mediated through hormones or substances synthesized and released by adipocytes, including leptin and adiponectin. Further, obesity is also a common feature of polycystic ovarian syndrome with hyperinsulinemia being the primary etiological factor. Here, we provide an overview of several endocrine syndromes known to result in obesity and discuss the endocrine role of adipose tissue in conjunction to its association with hypothalamic-pituitary-endocrine axes. For complete coverage of all related areas of Endocrinology, please visit our on-line FREE web-text, WWW.ENDOTEXT.ORG.

摘要

肥胖可能与下丘脑 - 垂体激素轴变化引起的多种内分泌改变有关。这些改变包括甲状腺功能减退、库欣病、性腺功能减退和生长激素缺乏。除了在能量储存中的作用外，脂肪组织还有许多其他重要功能，这些功能可通过脂肪细胞合成和释放的激素或物质介导，包括瘦素和脂联素。此外，肥胖也是多囊卵巢综合征的常见特征，高胰岛素血症是主要病因。在此，我们概述了几种已知会导致肥胖的内分泌综合征，并讨论脂肪组织的内分泌作用及其与下丘脑 - 垂体 - 内分泌轴的关系。如需全面涵盖内分泌学的所有相关领域，请访问我们的在线免费网络文本，网址为WWW.ENDOTEXT.ORG。