Dubey Abhishek, Kant Surya, Agarwal Sarita, Dixit Swati, Mahadi Abbas Ali, Tiwari Sunita
Indian J Physiol Pharmacol. 2014 Jul-Sep;58(3):222-8.
Obesity is an important risk factor of Obstructive Sleep Apnea Syndrome (OSAS). Previous studies suggested Leptin Receptor (LEPR) gene Polymorphisms is associated with obesity and OSAS. Study was conducted to asses association of LEPR gene polymorphism K109R, Q223R and K656N with OSAS in North Indian subjects. Genotyping and estimation of serum Leptin levels were done in 190 subjects. Polysomnography, anthropometrical measures and biochemical investigations were done in all the subjects who qualified for inclusion in the study. We observed significant association of Q223R gene polymorphism with blood pressure (BP) (P < 0.05) and nocturnal max pulse rate (P < 0.05). K656N gene polymorphism was associated with AHI (P < 0.05), average desaturation levels (P < 0.05) and HDL-C (P < 0.05). No association was observed in genotype distribution of these subjects according to obesity and disease severity. These findings suggest that LEPR Q223R and K656N gene Polymorphism may influence BP, Max Pulse rate, AHI, Average desaturation levels and HDL levels in these Subjects.
肥胖是阻塞性睡眠呼吸暂停低通气综合征（OSAS）的一个重要危险因素。先前的研究表明，瘦素受体（LEPR）基因多态性与肥胖和OSAS有关。本研究旨在评估北印度人群中LEPR基因多态性K109R、Q223R和K656N与OSAS的相关性。对190名受试者进行了基因分型和血清瘦素水平测定。对所有符合研究纳入标准的受试者进行了多导睡眠图检查、人体测量和生化检查。我们观察到Q223R基因多态性与血压（BP）（P < 0.05）和夜间最大脉搏率（P < 0.05）之间存在显著相关性。K656N基因多态性与呼吸暂停低通气指数（AHI）（P < 0.05）、平均血氧饱和度下降水平（P < 0.05）和高密度脂蛋白胆固醇（HDL-C）（P < 0.05）相关。根据肥胖和疾病严重程度，未观察到这些受试者的基因型分布存在关联。这些发现表明，LEPR Q223R和K656N基因多态性可能会影响这些受试者的血压、最大脉搏率、AHI、平均血氧饱和度下降水平和HDL水平。
