脑源性神经营养因子基因多态性与阻塞性睡眠呼吸暂停低通气综合征及肥胖的相关性

The Association of Brain-Derived Neurotrophic Factor Gene Polymorphism with Obstructive Sleep Apnea Syndrome and Obesity.

作者信息

Yüksekkaya Mehmet, Tutar Nuri, Büyükoğlan Hakan, Dündar Munis, Yılmaz İnsu, Gülmez İnci, Oymak Fatma Sema, Balta Burhan, Korkmaz Keziban, Demir Ramazan

机构信息

Department of Pulmonary Medicine, School of Medicine, Erciyes University, Kayseri, 38038, Turkey.

Department of Medical Genetics, School of Medicine, Erciyes University, Kayseri, Turkey.

出版信息

Lung. 2016 Oct;194(5):839-46. doi: 10.1007/s00408-016-9894-z. Epub 2016 May 11.

DOI:10.1007/s00408-016-9894-z

PMID:27166632

Abstract

BACKGROUND

Obesity represents a major risk factor for Obstructive Sleep Apnea Syndrome (OSAS). Brain-derived neurotrophic factor (BDNF) affects the mechanisms that regulate weight, eating behavior, and metabolism. This project aims to investigate the possible association of BDNF gene polymorphism with obesity and OSAS, and to contribute knowledge to the understanding of the pathophysiology of OSAS.

METHODS

The subjects included in this study were selected among the individuals who were hospitalized in the Erciyes University Medical School Chest Diseases Sleep Medicine Laboratory. Subjects were divided into four groups based on the presence of OSAS and/or obesity. Group 1 included OSAS+ obesity+ patients, Group 2 included OSAS+ obesity- patients, Group 3 included OSAS- obesity+ patients, and Group 4 included OSAS- obesity- patients. The targeted patient number per each study group was 45, but only 32 patients could be enrolled into Group 3.

RESULTS

Out of a total number of 167 subjects, 117 (70.1 %) had BDNF 196G/G, 48 (28.7 %) had BDNF 196G/A, and 2 (1.2 %) had BDNF 196A/A genotype. Of 48 subjects having BDNF 196G/A genotype, 32 (66.6 %) were obese, and 16 (33.3 %) were non-obese. Out of 90 subjects with OSAS, 64 (71.1 %) had BDNF 196G/G, and 25 (27.8 %) had BDNF 196G/A genotype. Out of 77 subjects without OSAS, BDNF 196G/G, and BDNF 196G/A genotypes were detected in 53 (68.8 %) and 23 (29.9 %) subjects, respectively. A statistically significant difference was demonstrated between the four study groups in terms of BDNF rs6265 polymorphism (p = 0.013). This difference was attributed to OSAS+ obesity- Group, in which BDNF 196G/G genotype was more common and BDNF 196G/A polymorphism was less common than the patients in other groups.

CONCLUSION

In conclusion, BDNF 196G/A genotype was found to be more frequent among obese patients compared to the non-obese individuals, but it was not significantly related to OSAS in the present study. BDNF196G/G genotype was more common and BDNF 196G/A polymorphism was less common among OSAS+ obesity- subjects compared to the other study groups.

摘要

背景

肥胖是阻塞性睡眠呼吸暂停综合征（OSAS）的主要危险因素。脑源性神经营养因子（BDNF）影响调节体重、饮食行为和新陈代谢的机制。本项目旨在研究BDNF基因多态性与肥胖和OSAS之间的可能关联，并为理解OSAS的病理生理学提供知识。

方法

本研究的受试者选自埃尔西耶斯大学医学院胸部疾病睡眠医学实验室住院的个体。根据是否存在OSAS和/或肥胖将受试者分为四组。第1组包括OSAS+肥胖+患者，第2组包括OSAS+肥胖-患者，第3组包括OSAS-肥胖+患者，第4组包括OSAS-肥胖-患者。每个研究组的目标患者数量为45，但第3组仅能招募32名患者。

结果

在总共167名受试者中，117名（70.1%）具有BDNF 196G/G基因型，48名（28.7%）具有BDNF 196G/A基因型，2名（1.2%）具有BDNF 196A/A基因型。在48名具有BDNF 196G/A基因型的受试者中，32名（66.6%）肥胖，16名（33.3%）非肥胖。在90名OSAS患者中，64名（71.1%）具有BDNF 196G/G基因型，25名（27.8%）具有BDNF 196G/A基因型。在77名无OSAS的受试者中，分别在53名（68.8%）和23名（29.9%）受试者中检测到BDNF 196G/G和BDNF 196G/A基因型。四个研究组在BDNF rs6265多态性方面存在统计学显著差异（p = 0.013）。这种差异归因于OSAS+肥胖-组，其中BDNF 196G/G基因型比其他组的患者更常见，而BDNF 196G/A多态性比其他组的患者更少见。