Vieweg W V, Godleski L S, Pulliam W R, Schofield W P, Saathoff G B, Hundley P L, Yank G R
Western State Hospital, Department of Mental Health and Mental Retardation, Staunton, VA 24401.
Biol Psychiatry. 1989 Dec;26(8):775-80. doi: 10.1016/0006-3223(89)90118-2.
We found abnormal diurnal weight gain among 25% of acutely psychotic patients with schizophrenia and 68% of chronically psychotic patients with schizophrenia. They were weighed at 7:00 AM and 4:00 PM weekly for 3 weeks. We normalized the diurnal weight gain (NDWG) as a percentage by subtracting the 7:00 AM weight from the 4:00 PM weight, multiplying the difference by 100, and dividing the result by the 7:00 AM weight, NDWG was 0.93% +/- 0.89% for the 36 acutely psychotic patients and 2.2% +/- 1.5% for the 68 chronically psychotic patients (F = 25.297, p less than 0.0001). Drugs did not explain this difference. Our data, though preliminary, suggest that water dysregulation, as manifested by abnormal diurnal weight gain, develops in schizophrenia as patients progress into Arieti's third stage of this disorder. A longitudinal study design, rather than our cross-sectional one, would be necessary to assess developmental changes in schizophrenia.
我们发现，25%的急性精神分裂症精神病患者和68%的慢性精神分裂症精神病患者存在异常的日间体重增加。在3周的时间里，每周上午7点和下午4点对他们进行称重。我们将日间体重增加（NDWG）标准化为一个百分比，方法是用下午4点的体重减去上午7点的体重，将差值乘以100，再将结果除以上午7点的体重。36名急性精神病患者的NDWG为0.93%±0.89%，68名慢性精神病患者的NDWG为2.2%±1.5%（F = 25.297，p < 0.0001）。药物并不能解释这种差异。我们的数据虽然是初步的，但表明随着精神分裂症患者发展到阿列蒂（Arieti）所描述的该疾病的第三阶段，异常的日间体重增加所表现出的水分调节失调会出现。需要采用纵向研究设计而非我们的横断面研究设计来评估精神分裂症的发展变化。
