Department of Pathology and Laboratory Medicine, University of British Columbia, and BC Cancer Agency, 675 West 10th Avenue, Vancouver V5Z 1L3, British Columbia, Canada.
Gastrointestinal Cancer Clinical Research Unit, Clinical Research Programme, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain.
Nat Rev Cancer. 2015 May;15(5):311-6. doi: 10.1038/nrc3944.
Patient-derived xenograft (PDX) models are now being widely used in cancer research and have the potential to greatly inform our understanding of cancer biology. However, many questions remain, especially regarding the ability of PDX models to affect clinical decision making. With these points in mind, we asked three scientists to give their opinions on the generation and uses of PDX models and the future of this field.
患者来源异种移植（PDX）模型目前正在癌症研究中得到广泛应用，有可能极大地促进我们对癌症生物学的理解。然而，仍有许多问题悬而未决，特别是关于 PDX 模型对临床决策的影响能力。考虑到这些要点，我们请三位科学家就 PDX 模型的生成和应用以及该领域的未来发表意见。
