Regional growth differences of human tumour xenografts in nude mice.

Human tumour cells of the HEP-2 and SW480 cell lines were inoculated subcutaneously into 4 locations on the athymic (nude) mouse lateral trunk. There was no difference in size between tumours grown on the right side of the body and those grown on the left. However, 4 weeks after inoculation, anterior tumours were 3 times as large as posterior tumours. The results indicate a predilection for tumour xenograft growth in the anterior region of the lateral nude mouse trunk.