Kim Dasom, Kim Jihye
Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Yongin, South Korea;
Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Yongin, South Korea; Research Institute of Medical Nutrition, Kyung Hee University, Seoul, South Korea.
Am J Hypertens. 2016 Jan;29(1):96-103. doi: 10.1093/ajh/hpv059. Epub 2015 Apr 23.
Previous studies have suggested that serum 25-hydroxyvitamin D [25(OH)D] and parathyroid hormone (PTH) levels are associated with hypertension. However, the associations have yet to be studied in Koreans. This study explored the relationship among serum 25(OH)D, PTH concentrations, and the presence of hypertension in middle-aged and older Korean adults using the most recent nationally representative survey data.
A population-based, cross-sectional study was conducted with data collected from 5,260 Korean adults (aged ≥50 years) who participated in the 2010 and 2011 Korean National Health and Nutrition Examination Surveys. Hypertension was defined as a systolic blood pressure ≥140 mm Hg, diastolic blood pressure ≥90 mm Hg, or current use of antihypertensive medication.
The prevalence of hypertension significantly increased according to the quartiles of serum PTH levels (P < 0.0001), but not of serum 25(OH)D levels. In multivariable logistic analysis, the adjusted odds ratios (ORs) for hypertension were significantly higher among participants in the highest quartile than among those in the lowest quartile of serum PTH level, after adjusting for potential confounders (OR = 1.26, 95% confidence interval: 1.02-1.56, P = 0.03). The adjusted ORs for hypertension tended to decrease across the quartiles of serum 25(OH)D level, but the associations were not significant.
Serum 25(OH)D was not associated with the presence of hypertension, whereas serum PTH was positively associated, suggesting that serum PTH may be an independent risk factor for hypertension in middle-aged and older Korean adults.
既往研究表明，血清25-羟维生素D[25(OH)D]和甲状旁腺激素（PTH）水平与高血压有关。然而，韩国人群中的这种关联尚未得到研究。本研究利用最新的全国代表性调查数据，探讨了韩国中老年成年人血清25(OH)D、PTH浓度与高血压之间的关系。
基于人群的横断面研究，数据来自于参加2010年和2011年韩国国民健康与营养检查调查的5260名韩国成年人（年龄≥50岁）。高血压定义为收缩压≥140mmHg、舒张压≥90mmHg或目前正在使用抗高血压药物。
高血压患病率随血清PTH水平四分位数显著增加（P<0.0001），但不随血清25(OH)D水平增加。在多变量逻辑分析中，校正潜在混杂因素后，血清PTH水平最高四分位数参与者的高血压校正比值比（OR）显著高于最低四分位数参与者（OR=1.26，95%置信区间：1.02-1.56，P=0.03）。高血压校正OR值随血清25(OH)D水平四分位数有降低趋势，但相关性不显著。
血清25(OH)D与高血压无关，而血清PTH呈正相关，提示血清PTH可能是韩国中老年成年人高血压的独立危险因素。
