Department of Neuroscience, Division of Geriatric Medicine, Angers University Hospital Angers University Memory Clinic UPRES EA 2646 University of Angers, Angers Cedex 9, France.
Geriatr Gerontol Int. 2013 Jul;13(3):783-91. doi: 10.1111/j.1447-0594.2012.00945.x. Epub 2012 Sep 19.
Serum parathyroid hormone (PTH) and 25-hydroxyvitamin D (25OHD) concentrations might contribute to blood pressure (BP) levels. Mixed results in previous literature could be due to the failure to consider both these hormones concurrently, despite their long-known relationship. Our objective was to examine the association of serum intact PTH and 25OHD concentrations with BP levels amongst older inpatients, while accounting for each other.
The participants were 284 Caucasian older inpatients with no suspicion of primary hyperparathyroidism (mean age 85.87 ± 5.90 years; 65.8% female) admitted to the geriatric acute care unit of Angers University Hospital, France. They were divided into two groups according to the existence of hypertension (i.e. systolic blood pressure [SBP] >140 mmHg, or diastolic blood pressure [DBP] >90 mmHg). Age, sex, numbers of chronic diseases and of drugs taken daily, use of antihypertensive or corticosteroid drugs and of calcium supplements/vitamin D, thyroid-stimulating hormone and albumin concentrations, creatinine clearance, and season tested were used as covariables.
Hypertensive participants (n=106) had higher intact PTH concentrations than normotensive patients (P=0.044). There was a positive linear association of BP with intact PTH concentrations (adjusted β=0.08, P=0.015 for SBP; adjusted β=0.05, P=0.044 for DBP), but not with vitamin D. Serum intact PTH concentration, unlike 25OHD, was associated with hypertension (adjusted OR 1.01, P=0.038).
Irrespective of 25OHD, PTH was associated with hypertension by increasing both SBP and DBP.
甲状旁腺激素（PTH）和 25-羟维生素 D（25OHD）的血清浓度可能与血压（BP）水平有关。之前的文献中存在混合结果，可能是由于未能同时考虑这两种激素，尽管它们之间的关系早已为人所知。我们的目的是在考虑彼此的情况下，检查血清完整 PTH 和 25OHD 浓度与老年住院患者 BP 水平之间的关系。
参与者为 284 名无原发性甲状旁腺功能亢进症怀疑的白人老年住院患者（平均年龄 85.87±5.90 岁；65.8%为女性），他们入住法国昂热大学医院老年急症护理病房。他们根据是否存在高血压（即收缩压[SBP]＞140mmHg，或舒张压[DBP]＞90mmHg）分为两组。使用年龄、性别、慢性病数量和每日服用药物数量、使用抗高血压或皮质类固醇药物和钙补充剂/维生素 D、促甲状腺激素和白蛋白浓度、肌酐清除率以及季节等作为协变量。
高血压患者（n=106）的完整 PTH 浓度高于血压正常患者（P=0.044）。BP 与完整 PTH 浓度呈正线性相关（校正后 SBP 的调整β=0.08，P=0.015；校正后 DBP 的调整β=0.05，P=0.044），但与维生素 D 无关。与 25OHD 不同，完整 PTH 浓度与高血压相关（校正后 OR 1.01，P=0.038）。
无论 25OHD 如何，PTH 通过增加 SBP 和 DBP 与高血压相关。
