Yuksel Nilay, Ozer Mediha Dilek, Takmaz Tamer, Ozen Umut, Metin Mustafa, Akcay Emine
Department of Ophthalmology, Ataturk Training and Research Hospital, Ankara - Turkey.
Department of Ophthalmology, Kahramanmaras Necip Fazil City Hospital, Kahramanmaras - Turkey.
Eur J Ophthalmol. 2015 Nov-Dec;25(6):512-5. doi: 10.5301/ejo.5000605. Epub 2015 Apr 9.
To investigate possible changes in anterior segment parameters with the Pentacam in patients taking tamsulosin or doxazosin for benign prostatic hyperplasia.
This prospective, cross-sectional study was conducted at Necip Fazil City Hospital, Kahramanmaras, Turkey. Patients included in the study were grouped as follows: 29 patients treated with tamsulosin (group 1), 27 patients treated with doxazosin (group 2), and 40 untreated controls (group 3). Right eyes of each patient were included in the study. All patients underwent examination with the Pentacam under standard dim light conditions and with undilated pupils. Anterior chamber depth (ACD), anterior chamber volume (ACV), anterior chamber angle (ACA) width, central corneal thickness (CCT), corneal volume (CV), and pupil diameter (PD) were recorded.
Mean duration of treatments was 2.7 ± 1.2 (1-5) and 2.4 ± 0.9 (1-5) years in groups 1 and 2 (p = 0.276). The ACD, ACV, ACA width, and PD were statistically significantly decreased in groups 1 and 2 when compared to group 3 (p<0.05). There were no statistically significant differences among the groups in mean values of CCT and CV.
In this study, decreased ACD, ACV, ACA width, and PD values were detected in tamsulosin and doxazosin groups when compared to controls. These findings should be considered during anterior segment examinations and surgeries.
研究服用坦索罗辛或多沙唑嗪治疗良性前列腺增生的患者，其眼前节参数使用Pentacam检查时可能出现的变化。
本前瞻性横断面研究在土耳其卡赫拉曼马拉什的内吉普·法齐尔市立医院进行。纳入研究的患者分为以下几组：29例接受坦索罗辛治疗的患者（第1组），27例接受多沙唑嗪治疗的患者（第2组），以及40例未治疗的对照者（第3组）。纳入研究的为每位患者的右眼。所有患者在标准暗光条件下且瞳孔未散大时接受Pentacam检查。记录前房深度（ACD）、前房容积（ACV）、前房角（ACA）宽度、中央角膜厚度（CCT）、角膜容积（CV）和瞳孔直径（PD）。
第1组和第2组的平均治疗时长分别为2.7±1.2（1 - 5）年和2.4±0.9（1 - 5）年（p = 0.276）。与第3组相比，第1组和第2组的ACD、ACV、ACA宽度和PD在统计学上显著降低（p<0.05）。各组之间CCT和CV的平均值无统计学显著差异。
在本研究中，与对照组相比，坦索罗辛组和多沙唑嗪组检测到ACD、ACV、ACA宽度和PD值降低。在眼前节检查和手术过程中应考虑这些发现。
