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基于急诊科监测登记处数据得出的中重度小儿颅脑损伤预测因素。

Predictors for moderate to severe paediatric head injury derived from a surveillance registry in the emergency department.

作者信息

Chong Shu-Ling, Barbier Sylvaine, Liu Nan, Ong Gene Yong-Kwang, Ng Kee Chong, Ong Marcus Eng Hock

机构信息

Department of Emergency Medicine, KK Women's and Children's Hospital, Singapore; SingHealth Duke-NUS Paediatrics Academic Clinical Programme, Duke-NUS Graduate Medical School, Singapore.

Centre for Quantitative Medicine,Duke-NUS Graduate Medical School, Singapore.

出版信息

Injury. 2015 Jul;46(7):1270-4. doi: 10.1016/j.injury.2015.04.002. Epub 2015 Apr 15.

Abstract

INTRODUCTION AND AIM

Head injuries are a common complaint among children presenting to the emergency department (ED). This study is part of an ongoing prospective surveillance of head injured children presenting to a paediatric ED. We aim to derive predictors for moderate to severe head injury in our population.

MATERIALS AND METHODS

We performed an unmatched case-control study. Cases were defined as those who presented to the ED with moderate to severe head injury, during the period from 2006 to 2014. Controls were obtained from the prospective surveillance head injury database and were children who presented to the ED with head injury but who remained well on follow up. We compared variables from demographics, mechanism of injury, history, and physical examination.

RESULTS

There were 39 cases and 1173 controls. In the prospective database, our event rate was 0.5% and our computed tomography (CT) rate was 1%. Among those with moderate to severe head injury, they were more likely to be involved in road traffic accidents, have a history of difficult arousal, confusion or disorientation and a history of seizure. On physical examination, cases were more likely to have the presence of altered mental status, base of skull fracture, scalp hematoma and anisocoria. On multivariable analysis, the following 4 predictors remained statistically significant: Involvement in road traffic accident (p<0.001), difficult arousal (p<0.001), vomiting (p=0.003) and signs of base of skull fracture (p<0.001). Using these 4 variables, the Area under Curve was 0.97 {Sensitivity 92.3% (79.1-98.4%), Specificity 93.0% (91.4-94.4%), positive predictive value 30.5% (22-40%), negative predictive value 99.7% (99.2-99.9%)}.

CONCLUSION

Involvement in road traffic accident, difficult arousal, base of skull fracture and vomiting are independent predictors for moderate to severe head injury in our paediatric population.

摘要

引言与目的

头部损伤是前往急诊科(ED)就诊的儿童的常见病症。本研究是对前往儿科急诊科就诊的头部受伤儿童进行的一项正在进行的前瞻性监测的一部分。我们旨在得出我们研究人群中中度至重度头部损伤的预测因素。

材料与方法

我们进行了一项非匹配病例对照研究。病例定义为在2006年至2014年期间前往急诊科就诊且患有中度至重度头部损伤的患者。对照从前瞻性监测头部损伤数据库中选取,是前往急诊科就诊但在随访中情况良好的头部受伤儿童。我们比较了人口统计学、损伤机制、病史和体格检查等方面的变量。

结果

有39例病例和1173例对照。在前瞻性数据库中,我们的事件发生率为0.5%,计算机断层扫描(CT)率为1%。在中度至重度头部损伤患者中,他们更有可能卷入道路交通事故,有难以唤醒、意识模糊或定向障碍病史以及癫痫病史。在体格检查中,病例更有可能出现精神状态改变、颅骨骨折、头皮血肿和瞳孔不等大。在多变量分析中,以下4个预测因素在统计学上仍具有显著意义:卷入道路交通事故(p<0.001)、难以唤醒(p<0.001)、呕吐(p=0.003)和颅骨骨折体征(p<0.001)。使用这4个变量,曲线下面积为0.97 {敏感性92.3%(79.1 - 98.4%),特异性93.0%(91.4 - 94.4%),阳性预测值30.5%(22 - 40%),阴性预测值99.7%(99.2 - 99.9%)}。

结论

卷入道路交通事故、难以唤醒、颅骨骨折和呕吐是我们儿科人群中中度至重度头部损伤的独立预测因素。

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