与前列腺癌相关的hOGG1 C1245G基因多态性：一项荟萃分析。

hOGG1 C1245G gene polymorphism associated with prostate cancer: a meta-analysis.

作者信息

Chen Yang, Li Jie, Li Tianyu, Mo Zengnan

机构信息

1 Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region - PR China.

出版信息

Int J Biol Markers. 2015 May 26;30(2):e161-8. doi: 10.5301/jbm.5000144.

DOI:10.5301/jbm.5000144

PMID:25907663

Abstract

BACKGROUND

Prostate cancer (Pca) is one of the most frequently encountered multifactorial malignant diseases worldwide. The human oxoguanine glycosylase 1 (hOGG1) C1245G polymorphism (rs1052133) has been found to be associated with Pca. However, the conclusions have been controversial.

METHODS

Based on the PubMed, Embase, HuGENet and Chinese National Knowledge Infrastructure (CNKI) databases, this meta-analysis was conducted with 4 models. Eleven qualified studies were included.

RESULTS

Although no positive relation was discovered in the pooled analysis, significant associations between rs1052133 and Pca were found in the Asian population (recessive: odds ratio [OR] = 1.580, 95% confidence interval [95% CI], 1.189-2.098; GG vs. GC: OR = 1.504, 95% CI, 1.114-2.030; GG vs. CC: OR = 1.677, 95% CI, 1.201-2.342; allele analysis: OR = 1.249, 95% CI, 1.077-1.449), whites (dominant: OR = 2.138, 95% CI, 1.483-3.083; recessive: OR = 3.143, 95% CI, 1.171-8.437; GG vs. CC: OR = 3.992, 95% CI, 1.891-8.431; allele analysis: OR = 1.947, 95% CI, 1.467-2.586) and mixed populations (recessive: OR = 0.636, 95% CI, 0.484-0.834; GG vs. GC: OR = 0.654, 95% CI, 0.492-0.871; GG vs. CC: OR = 0.624, 95% CI, 0.473-0.823; allele analysis: OR = 0.857, 95% CI, 0.771-0.954). After excluding studies deviating from the Hardy-Weinberg equilibrium, a significant association was also found in the same ethnic groups. In addition, a new positive relation was identified in the "other country" subgroup (with China, South Korea and Australia included) (dominant: OR = 1.622, 95% CI, 1.163-2.261; recessive: OR = 1.773, 95% CI, 1.308-2.404; GG vs. GC: OR = 1.614, 95% CI, 1.169-2.230; GG vs. CC: OR = 2.108, 95% CI, 1.456-3.051; allele analysis: OR = 1.494, 95% CI, 1.235-1.808) and among the Chinese-Korean population.

CONCLUSIONS

In conclusion, we suggest that the hOGG1 C1245G polymorphism might be potentially associated with Pca risk in different ethnicities and countries, especially among Asians. Further studies are needed to confirm these relations.

摘要

背景

前列腺癌（Pca）是全球最常见的多因素恶性疾病之一。已发现人类氧鸟嘌呤糖基化酶1（hOGG1）C1245G多态性（rs1052133）与前列腺癌相关。然而，结论一直存在争议。

方法

基于PubMed、Embase、HuGENet和中国国家知识基础设施（CNKI）数据库，采用4种模型进行此项荟萃分析。纳入了11项合格研究。

结果

尽管在汇总分析中未发现阳性关联，但在亚洲人群（隐性模型：比值比[OR]=1.580，95%置信区间[95%CI]，1.189 - 2.098；GG与GC比较：OR = 1.504，95%CI，1.114 - 2.030；GG与CC比较：OR = 1.677，95%CI，1.201 - 2.342；等位基因分析：OR = 1.249，95%CI，1.077 - 1.449）、白人（显性模型：OR = 2.138，95%CI，1.483 - 3.083；隐性模型：OR = 3.143，95%CI，1.171 - 8.437；GG与CC比较：OR = 3.992，95%CI，1.891 - 8.431；等位基因分析：OR = 1.947，95%CI，1.467 - 2.586）和混合人群（隐性模型：OR = 0.636，95%CI，0.484 - 0.834；GG与GC比较：OR = 0.654，95%CI，0.492 - 0.871；GG与CC比较：OR = 0.624，95%CI，0.473 - 0.823；等位基因分析：OR = 0.857，95%CI，0.771 - 0.954）中发现rs1052133与前列腺癌存在显著关联。排除偏离哈迪 - 温伯格平衡的研究后，在相同种族群体中也发现了显著关联。此外，在“其他国家”亚组（包括中国、韩国和澳大利亚）（显性模型：OR = 1.622，95%CI，1.163 - 2.261；隐性模型：OR = 1.773，95%CI，1.308 - 2.404；GG与GC比较：OR = 1.614，95%CI，1.169 - 2.230；GG与CC比较：OR = 2.108，95%CI，1.456 - 3.051；等位基因分析：OR = 1.494，95%CI，1.235 - 1.808）以及中韩人群中发现了一种新的阳性关联。