HOGG1基因Ser326Cys多态性与头颈癌易感性：一项荟萃分析。

HOGG1 Ser326Cys polymorphism and susceptibility to head and neck cancer: a meta-analysis.

作者信息

Liu Jun, Cao Xiao-Lin, Zhang Zhen, Lei Da-Peng, Jin Tong, Yu Xue-Min, Pan Xin-Liang

机构信息

Department of Otolaryngology, Qilu Hospital, Shandong University, Jinan, China.

出版信息

Asian Pac J Cancer Prev. 2011;12(10):2491-4.

PMID:22320944

Abstract

PURPOSE

Several research groups have investigated the influence of the human 8-oxoguanine DNA glycosylase 1 (hOGG1) Ser326Cys polymorphism on head and neck cancer (HNC) susceptibility. However, the results remain inconclusive and controversial. We therefore conducted the present meta-analysis.

METHODS

Relevant studies were identified through a search of PubMed databases until July 2011 and selected on the basis of established inclusion criteria for publications.

RESULTS

A total of 8 case-control studies on the association of hOGG1 Ser326Cys polymorphism with HNC risk were included in the present meta-analysis. Overall significant associations were observed (G allele vs. C allele: OR=1.49, 95%CI=1.08-2.05, P<0.01 for heterogeneity; GG vs.CC: OR=2.30, 95%CI=1.05-5.05, P<0.01 for heterogeneity; CG vs. CC: OR=1.40, 95%CI=1.03-1.90, P<0.01 for heterogeneity; dominant model (GG+CG vs. CC): OR=1.52, 95%CI=1.06-2.16, P<0.01 for heterogeneity; recessive model (GG vs. CG+CC): OR=2.04, 95%CI=1.05-3.96, P=0.01 for heterogeneity) after excluding the studies that were not in agreement with HWE. On performance of a subgroup meta-analysis by ethnicity, significant associations were found (G allele vs. C allele: OR=1.40, 95%CI=1.001-1.95, P<0.01 for heterogeneity; GG vs.CC: OR=2.30, 95%CI=1.05-5.05, P<0.01 for heterogeneity; recessive model (GG vs. CG+CC): OR=2.04, 95%CI=1.05-3.96, P=0.01 for heterogeneity) in Caucasian populations after excluding one study not in agreement with HWE.

CONCLUSIONS

Our results suggested that the G allele might be associated with an increased risk of HNC in Caucasian populations.

摘要

目的

多个研究小组已对人类8-氧代鸟嘌呤DNA糖基化酶1（hOGG1）Ser326Cys多态性对头颈部癌（HNC）易感性的影响进行了研究。然而，结果仍不明确且存在争议。因此，我们进行了本次荟萃分析。

方法

通过检索PubMed数据库直至2011年7月来确定相关研究，并根据既定的纳入标准选择发表的文献。

结果

本次荟萃分析共纳入了8项关于hOGG1 Ser326Cys多态性与HNC风险关联的病例对照研究。排除不符合哈迪-温伯格平衡（HWE）的研究后，观察到总体存在显著关联（G等位基因与C等位基因：OR = 1.49，95%CI = 1.08 - 2.05，异质性P < 0.01；GG与CC：OR = 2.30，95%CI = 1.05 - 5.05，异质性P < 0.01；CG与CC：OR = 1.40，95%CI = 1.03 - 1.90，异质性P < 0.01；显性模型（GG + CG与CC）：OR = 1.52，95%CI = 1.06 - 2.16，异质性P < 0.01；隐性模型（GG与CG + CC）：OR = 2.04，95%CI = 1.05 - 3.96，异质性P = 0.01）。按种族进行亚组荟萃分析时，排除一项不符合HWE的研究后，在白种人群中发现了显著关联（G等位基因与C等位基因：OR = 1.40，95%CI = 1.001 - 1.95，异质性P < 0.01；GG与CC：OR = 2.30，95%CI = 1.05 - 5.05，异质性P < 0.01；隐性模型（GG与CG + CC）：OR = 2.04，95%CI = 1.05 - 3.96，异质性P = 0.01）。