通过蛋白质组学改变免疫介导性肾小球疾病的观念。
Changing the concepts of immune-mediated glomerular diseases through proteomics.
机构信息
Department of Medicine, University of Louisville School of Medicine, Louisville, KY, USA.
Robley Rex VA Medical Center, Louisville, KY, USA.
出版信息
Proteomics Clin Appl. 2015 Dec;9(11-12):967-71. doi: 10.1002/prca.201400159. Epub 2015 Jun 17.
Standard classification of glomerular diseases is based on histopathologic abnormalities. The recent application of proteomic technologies has resulted in paradigm changes in the understanding and classification of idiopathic membranous nephropathy and membranoproliferative glomerulonephritis. Those examples provide evidence that proteomics will lead to advances in understanding of the molecular basis of other glomerular diseases, such as lupus nephritis. Proof of principle experiments show that proteomics can be applied to patient renal biopsy specimens. This viewpoint summarizes the advances in immune-mediated glomerular diseases that have relied on proteomics, and potential future applications are discussed.
肾小球疾病的标准分类基于组织病理学异常。最近蛋白质组学技术的应用导致特发性膜性肾病和膜增生性肾小球肾炎的理解和分类发生了范式转变。这些例子证明蛋白质组学将导致对其他肾小球疾病（如狼疮性肾炎）的分子基础的理解取得进展。原理验证实验表明，蛋白质组学可以应用于患者的肾活检标本。这一观点总结了依赖蛋白质组学的免疫介导性肾小球疾病的进展，并讨论了潜在的未来应用。
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