再激发时氯氮平引起的抗精神病药恶性综合征及其锥体外系效应。
Zuclopenthixol-induced neuroleptic malignant syndrome at rechallenge and its extrapyramidal effects.
作者信息
Kemperman C J
机构信息
Department of Psychiatry, State University Hospital, Groningen, The Netherlands.
出版信息
Br J Psychiatry. 1989 Apr;154:562-3. doi: 10.1192/bjp.154.4.562.
PMID:2590791
Abstract
This is the first report of a zuclopenthixol-induced NMS. The lack of previous reports may be because the receptor-binding profile of thioxanthenes give rise to fewer extrapyramidal effects than comparable neuroleptics. It is important to know more of the relationship between the potential for induction of extrapyramidal effects and success in NMS rechallenge.
摘要
这是关于珠氯噻醇诱发神经精神性恶性综合征（NMS）的首例报告。此前缺乏相关报告可能是因为硫杂蒽类药物的受体结合特性相比同类抗精神病药物会产生较少的锥体外系效应。进一步了解锥体外系效应诱发可能性与NMS再激发成功之间的关系很重要。
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