Griguolo Gaia, Mazzucchelli Luca, Cavalli Franco, Ceriani Luca, Zucca Emanuele, Stathis Anastasios
1 Lymphoma Unit, Oncology Institute of Southern Switzerland, Bellinzona - Switzerland.
Tumori. 2015 Jun 25;101(3):e99-e102. doi: 10.5301/tj.5000283.
Hodgkin lymphoma (HL) is an uncommon monoclonal lymphoid malignancy consisting of 2 main entities: classical HL and nodular lymphocyte predominant. Hodgkin lymphoma usually presents with peripheral lymphadenopathies, while extranodal involvement is rare. Prevalent osseous presentation is rare and still misdiagnosed, despite improvements in diagnostic techniques. Here we report the case of a 30-year-old man with multifocal HL bone involvement initially misdiagnosed as chronic recurrent osteomyelitis. This case emphasizes the difficulties in the diagnosis of HL presenting with bone pain and with radiologic skeletal findings not specific for lymphoma. These patients often have diagnostic delays and misdiagnosis. Repeated investigations and clinical suspicion of unusual presentations may be helpful in order to establish a correct diagnosis and start an effective treatment in this highly curable disease.
霍奇金淋巴瘤（HL）是一种罕见的单克隆淋巴恶性肿瘤，主要由两个实体组成：经典型HL和结节性淋巴细胞为主型。霍奇金淋巴瘤通常表现为外周淋巴结病，而结外受累罕见。尽管诊断技术有所改进，但常见的骨表现仍然罕见且仍会被误诊。在此，我们报告一例30岁男性多灶性HL骨受累病例，最初被误诊为慢性复发性骨髓炎。该病例强调了诊断以骨痛为表现且影像学骨骼表现不具有淋巴瘤特异性的HL的困难。这些患者常常诊断延迟且被误诊。反复检查以及对不寻常表现的临床怀疑可能有助于在此种高度可治愈疾病中确立正确诊断并开始有效治疗。
