二氢庚基戊烯醇对犊牛中性粒细胞功能的影响。

Effects of dihydroheptaprenol on neutrophil functions in calves.

作者信息

Yoneyama O, Osame S, Ichijo S, Kimura M, Araki S, Suzuki M, Imamura E

出版信息

Br Vet J. 1989 Nov-Dec;145(6):531-7. doi: 10.1016/0007-1935(89)90114-0.

DOI:10.1016/0007-1935(89)90114-0

Abstract

Microemulsified dihydroheptaprenol (DHP) was administered intramuscularly to clinically healthy calves at doses of 4, 6 and 8 mg/kg body weight. Marked increase of neutrophil counts was observed 0.5, 1 and 2 days after the injection at a dose of 6 mg/kg. Nitroblue tetrazolium reducing activity of neutrophils was also obviously enhanced 1, 2 and 3 days after DHP administration. Phagocytic killing of Staphylococcus aureus by neutrophils was further enhanced markedly 1, 2 and 3 days after the drug injection at 6 mg/kg.

摘要

将微乳化二氢庚烯醇（DHP）以4、6和8毫克/千克体重的剂量肌肉注射给临床健康的小牛。在以6毫克/千克的剂量注射后0.5、1和2天观察到中性粒细胞计数显著增加。在给予DHP后1、2和3天，中性粒细胞的硝基蓝四氮唑还原活性也明显增强。在以6毫克/千克的剂量注射药物后1、2和3天，中性粒细胞对金黄色葡萄球菌的吞噬杀伤作用进一步显著增强。